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Fig. 6 | Alzheimer's Research & Therapy

Fig. 6

From: Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer’s-like mice

Fig. 6

07/2a and 07/2a-k immunotherapy lowers Aβ in hAPPSL:hQC mice. Quantitative image analysis of the hippocampus on six stained sections at three equidistant planes per marker demonstrated that there was a significant reduction of pGlu-3 Aβ following 4 months of treatment with 07/2a at 150 μg (p < 0.05), 07/2a at 500 μg (p < 0.01), and 07/2a-k at 500 μg (p < 0.05) (a). General Aβ as measured by R1282 IHC demonstrated a reduction after dosing with 07/2a at 150 μg (p < 0.05), 07/2a at 500 μg (p < 0.01), and 07/2a-k at 500 μg (p < 0.01) (b). Aβx-42 levels measured in the TBS soluble fraction were reduced in the brains of animals treated with 07/2a at 150 μg (p < 0.05), 07/2a at 500 μg (p < 0.01), and 07/2a-k at 500 μg (p < 0.05) (c). n = 7–8 mice per group. All data are expressed as the mean ± SEM. ANOVA with Bartlett’s post test: ***p < 0.001, **p < 0.01, and *p < 0.05 versus isotype control

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