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Table 3 Included participants in EPAD Longitudinal cohort study per recruitment setting

From: Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort: impact of AD risk factors and recruitment settings

 Toulouse RegistryALFA StudyGeneration ScotlandpilotHO.nl
CSF Aβ +veCSF Aβ normalCSF Aβ +veCSF Aβ normalCSF Aβ +veCSF Aβ normalCSF Aβ +veCSF Aβ normal
n2341368822392649
Age, year71 (5)67 (8)^64 (6)64 (5)71 (3)67 (5)#68 (6)66 (7)
Male, n (%)4 (17%)17 (41%)23 (64%)41 (47%)14 (61%)23 (57%)14 (52%)19 (37%)
MMSE (30–0)28.0 (2.1)28.8 (1.7)28.6 (1.1)28.7 (1.6)28.1 (1.6)28.8 (1.4)28.4 (1.5)29.1 (1.3)
CDR-SOB (0–18)0.74 (0.7)0.34 (0.5)^0.10 (0.3)0.05 (0.2)0.15 (0.3)0.06 (0.2)0.06 (0.2)0.02 (0.1)
CSF Aβ1–42, pg/mL756 (195)1613 (361)#823 (191)1696 (519)#748 (251)1769 (411)#846 (217)1788 (443)#
CSF P-tau, pg/mL29 (15)18 (4.9)$21 (15)17 (7)19 (9)21 (12)21 (10)17 (5)
CSF T-tau, pg/mL305 (125)210 (53)$223 (132)209 (79)211 (81)249 (115)*240 (101)206 (58)
MTA (0–4)0.4 (0.5)0.2 (0.4)0.2 (0.4)0.1 (0.3)0.4 (0.6)0.1 (0.4)0.2 (0.4)0.2 (0.4)
Fazekas (0–3)1.1 (0.7)0.8 (0.7)1 (0.6)0.8 (0.6)1.1 (0.9)0.7 (0.7)^0.9 (0.8)0.9 (0.7)
  1. Legend: MMSE Mini-Mental State Examination, CDR-SOB Clinical Dementia Rating scale- Sum Of Boxes, CSF cerebrospinal fluid, P-tau phosphorylated tau, T-tau total tau, MTA medial temporal lobe atrophy. Mean (SD) unless otherwise specified. *One outlier at t-tau 792 and p-tau 81. Undetectably low p-tau and t-tau was set at the detection border of 8 and 80 respectively, Aβ1–42 was extrapolated. Raw p < 0.05 = ^; p < 0.01 = $, p < 0.001 = #