Table 2 Recruitment flow from EPAD Registry by recruitment setting
| Â | Â | Cohorts | Total | |||
|---|---|---|---|---|---|---|
Toulouse Registry | ALFA Study | Generation Scotland | pilotHO.nl | Â | ||
| Â | Setting | Memory clinic | In-person research cohort | Population-based | Online research cohort | Â |
Step 1 | Selection by PREPAD tool | 169 | 618 | 1947 | 275 | 3009 |
Step 2 | Not eligible based database check | 11 | 347 | 1 | 55 | 414 |
|  | • Exclusion criterion | 10 | 110 | 1 | 29 | 150 |
|  | • Other | 1 | 237 | 0 | 26 | 264 |
| Â | Number selected for step 3 (% from step 1) | 158 (93%) | 271 (44%) | 1946 (100%) | 220 (80%) | 2595 (86%) |
Step 3 | Not eligible after contacting participant | 65 | 119 | 1879 | 119 | 2182 |
|  | • No interest | 64 | 24 | 178 | 83 | 349 |
|  | • No response to letter | NA | NA | 1470 | NA | 1470 |
|  | • Exclusion criterion | 0 | 37 | 12 | 24 | 73 |
|  | • Other | 1 | 58 | 219 | 12 | 290 |
| Â | Number selected for step 4 (% from step 3) | 93 (59%) | 152 (56%) | 67 (3%) | 101 (46%) | 413 (16%) |
Step 4 | EPAD-LCS screening visit | 70 | 137 | 67 | 88 | 362 |
|  | Eligible & CSF Aβ1–42 analysed | 64 | 124 | 61 | 75 | 324 |
|  | • CSF Aβ1–42 < 1098 pg/mL (positivity) | 23 (36%) | 36 (29%) | 22 (36%) | 26 (35%) | 107 (33%) |
| Â | Number needed to screen | 3.0 | 3.8 | 3.0 | 3.4 | 3.4 |
| Â | Number needed to prescreen | 6.9 | 7.5 | 88.5 | 8.5 | 24.3 |