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Table 1 Baseline available data and characteristics of cohorts

From: Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort: impact of AD risk factors and recruitment settings

 Toulouse RegistryALFAGeneration ScotlandpilotHO.nl
SettingMemory clinicIn-person research cohortPopulation-basedOnline research cohort
N195258913,681412
Age, year68 (7)60 (6)64 (9)65 (9)
Male, n (%)56 (29%)962 (37%)5399 (39%)155 (38%)
Highly educated, n (%) (n = 15,239)*97 (60%)1225 (47%)4860 (40%)313 (77%)
APOE ɛ4 genotype, n (%) (n = 16,185)NA872 (34%)3695 (28%)84 (31%)
Family history for dementia, n (%) (n = 16,844)131 (71%)2470 (95%)1386 (10%)193 (50%)
Subjective cognitive decline, n (%) (n = 3175)^151 (83%)312 (12%)NA81 (20%)
% low memory, n (%) (n = 16,420)$17 (15%)242 (9%)1684 (12%)20 (9%)
Diagnosed with MCI, n (%)#13 (7%)03 (0%)4 (1%)
Estimated amyloid-positive individuals based on [4], taking into account age-bins, n (%) &~ 40 (22%)~ 430 (17%)~ 2680 (20%)~ 80 (20%)
  1. Legend: * high education: Toulouse Registry: > = 14 years; ALFA Study: > = 14 years; GS: > = 14 years; pilotHO.nl: > = 6 on the Verhage scale. ^SCD: Toulouse Registry: physician diagnosis and MCI patients excluded; ALFA Study: memory complaints question; pilotHO.nl: questions on memory complaints with worries; $Low memory delayed recall z-score < − 1.28: Toulouse Registry: FCSRT delayed recall, normalised by formula (score-11)/2, at raw score cut-off < 9; ALFA Study: memory binding test, normalised to sample, at raw score cut-off < 18; GS: Wechsler logical memory - delayed recall was normalised, at raw score cut-off < 9; pilotHO.nl: online Muistikko-test, normalised to sample, at raw score cut-off < 9. #MCI: Toulouse Registry: physician diagnosis; pilotHO.nl and Generation Scotland self-report. In the ALFA study no MCI patients were enrolled. &Formula based on Janssen et al. [4] (N age bin 50 to 57.5 years) × 12.9% + (N age bin 57.5 to 62.5 years) × 15.8% + (N age bin 62.5 to 67.5 years) × 19.2% + (N age bin 67.5 to 72.5 years) × 23.1% + (N age bin 72.5 to 77.5 years) × 27.6% + (N age bin 77.5 to 82.5 years) × 32.6% + (N age bin 82.5 years and older) × 38%