Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort: impact of AD risk factors and recruitment settings

Table 1 Baseline available data and characteristics of cohorts

	Toulouse Registry	ALFA	Generation Scotland	pilotHO.nl
Setting	Memory clinic	In-person research cohort	Population-based	Online research cohort
N	195	2589	13,681	412
Age, year	68 (7)	60 (6)	64 (9)	65 (9)
Male, n (%)	56 (29%)	962 (37%)	5399 (39%)	155 (38%)
Highly educated, n (%) (n = 15,239)^*	97 (60%)	1225 (47%)	4860 (40%)	313 (77%)
APOE ɛ4 genotype, n (%) (n = 16,185)	NA	872 (34%)	3695 (28%)	84 (31%)
Family history for dementia, n (%) (n = 16,844)	131 (71%)	2470 (95%)	1386 (10%)	193 (50%)
Subjective cognitive decline, n (%) (n = 3175)^{^}	151 (83%)	312 (12%)	NA	81 (20%)
% low memory, n (%) (n = 16,420)^$	17 (15%)	242 (9%)	1684 (12%)	20 (9%)
Diagnosed with MCI, n (%)^#	13 (7%)	0	3 (0%)	4 (1%)
Estimated amyloid-positive individuals based on [4], taking into account age-bins, n (%) ^&	~ 40 (22%)	~ 430 (17%)	~ 2680 (20%)	~ 80 (20%)

Legend: ^* high education: Toulouse Registry: > = 14 years; ALFA Study: > = 14 years; GS: > = 14 years; pilotHO.nl: > = 6 on the Verhage scale. ^{^}SCD: Toulouse Registry: physician diagnosis and MCI patients excluded; ALFA Study: memory complaints question; pilotHO.nl: questions on memory complaints with worries; ^$Low memory delayed recall z-score < − 1.28: Toulouse Registry: FCSRT delayed recall, normalised by formula (score-11)/2, at raw score cut-off < 9; ALFA Study: memory binding test, normalised to sample, at raw score cut-off < 18; GS: Wechsler logical memory - delayed recall was normalised, at raw score cut-off < 9; pilotHO.nl: online Muistikko-test, normalised to sample, at raw score cut-off < 9. ^#MCI: Toulouse Registry: physician diagnosis; pilotHO.nl and Generation Scotland self-report. In the ALFA study no MCI patients were enrolled. ^&Formula based on Janssen et al. [4] (N age bin 50 to 57.5 years) × 12.9% + (N age bin 57.5 to 62.5 years) × 15.8% + (N age bin 62.5 to 67.5 years) × 19.2% + (N age bin 67.5 to 72.5 years) × 23.1% + (N age bin 72.5 to 77.5 years) × 27.6% + (N age bin 77.5 to 82.5 years) × 32.6% + (N age bin 82.5 years and older) × 38%

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