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Table 3 Generalized estimation equation results show the interactive effect of left MFC connectivity and amyloid deposition on two specific cognitive domains, attention/processing speed, and executive function, adjusting for demographic data, neurodegenerative biomarkers, and time effect. *p < 0.05; **p < 0.01; ***p < 0.001

From: The effect of amyloid deposition on longitudinal resting-state functional connectivity in cognitively normal older adults

 β (unstandardized)Standard error
Predicting changes in attention and processing speed cognitive domain
 Intercept0.1283.304
 Sex (M:F)− 0.511*0.241
 Education (years)0.0770.043
 Race (B:W)0.884*0.413
 Age (years)− 0.0510.024
 Intracranial volume (cubic mm)0.000*0.000
 Time (years)− 0.0110.047
 glucose metabolism (FDG SUVR)− 0.0540.899
 Normalized hippocampal volume309.237*129.011
 Normalized WMH volume0.4710.345
 amyloid (PiB SUVR)− 0.844*0.382
 MFG connectivity with memory encoding network1.815**0.524
 Amyloid × MFG connectivity− 1.056***0.292
Predicting changes in executive function cognitive domain
 Intercept5.544*2.261
 Sex (M:F)− 0.3570.243
 Education (years)0.0550.041
 Race (B:W)− 0.2920.424
 Age (years)− 0.055*0.022
 Intracranial volume (cubic mm)0.0000.000
 Time (years)0.0220.060
 glucose metabolism (FDG SUVR)0.7160.833
 Normalized hippocampal volume186.491131.311
 Normalized WMH volume0.595*0.247
 amyloid (PiB SUVR)− 2.205***0.611
 MFG connectivity with memory encoding network1.926***0.511
 Amyloid × MFG connectivity− 1.384***0.330
  1. In the model predicting changes in attention and processing speed, significant variables include sex (p=0.034), age (p=0.031), race (p=0.032), ICV (p=0.012), normalized hippocampal volume (p=0.012), amyloid (p=0.027), MFG connectivity with memory encoding network(p=0.001), and amyloid x MFG connectivity (p< 0.001) ; In the model predicting changes in executive function, significant variables include age (p=0.013), amyloid (p< 0.001), MFG connectivity with memory encoding network (p< 0.001) and amyloid × MFG connectivity (p< 0.001).