Table 3 Generalized estimation equation results show the interactive effect of left MFC connectivity and amyloid deposition on two specific cognitive domains, attention/processing speed, and executive function, adjusting for demographic data, neurodegenerative biomarkers, and time effect. *p < 0.05; **p < 0.01; ***p < 0.001
β (unstandardized) | Standard error | |
|---|---|---|
Predicting changes in attention and processing speed cognitive domain | ||
Intercept | 0.128 | 3.304 |
Sex (M:F) | − 0.511* | 0.241 |
Education (years) | 0.077 | 0.043 |
Race (B:W) | 0.884* | 0.413 |
Age (years) | − 0.051 | 0.024 |
Intracranial volume (cubic mm) | 0.000* | 0.000 |
Time (years) | − 0.011 | 0.047 |
glucose metabolism (FDG SUVR) | − 0.054 | 0.899 |
Normalized hippocampal volume | 309.237* | 129.011 |
Normalized WMH volume | 0.471 | 0.345 |
amyloid (PiB SUVR) | − 0.844* | 0.382 |
MFG connectivity with memory encoding network | 1.815** | 0.524 |
Amyloid × MFG connectivity | − 1.056*** | 0.292 |
Predicting changes in executive function cognitive domain | ||
Intercept | 5.544* | 2.261 |
Sex (M:F) | − 0.357 | 0.243 |
Education (years) | 0.055 | 0.041 |
Race (B:W) | − 0.292 | 0.424 |
Age (years) | − 0.055* | 0.022 |
Intracranial volume (cubic mm) | 0.000 | 0.000 |
Time (years) | 0.022 | 0.060 |
glucose metabolism (FDG SUVR) | 0.716 | 0.833 |
Normalized hippocampal volume | 186.491 | 131.311 |
Normalized WMH volume | 0.595* | 0.247 |
amyloid (PiB SUVR) | − 2.205*** | 0.611 |
MFG connectivity with memory encoding network | 1.926*** | 0.511 |
Amyloid × MFG connectivity | − 1.384*** | 0.330 |