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Table 2 Generalized estimation equation results modeling significant changes over time (mean duration of 2 years) in connectivity. MFG connectivity significantly increased by 0.264 units per year, which was lower by 0.1 units per unit PiB SUVR. *p < 0.05; **p < 0.01; ***p < 0.001

From: The effect of amyloid deposition on longitudinal resting-state functional connectivity in cognitively normal older adults

Predicting changes in MFG connectivity with memory encoding network
 β (unstandardized)Standard error
Intercept− 1.5321.976
Covariates of no interest  
Sex (M:F)− 0.0120.123
Education (years)0.0150.018
Race (B:W)0.0320.253
Age (years)0.0150.010
Intracranial volume (cubic mm)0.0000.000
 Time (years)0.264*0.065
  amyloid (PiB SUVR)− 0.0490.237
  glucose metabolism (FDG SUVR)− 0.0340.516
  Normalized hippocampal volume− 13.85361.567
  Normalized WMH volume0.0630.092
 Time × PiB− 0.100*0.031
  Time × FDGNot significant, not included
  Time × hippocampal volumeNot significant, not included
  Time × WMH volumeNot significant, not included