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Table 2 Generalized estimation equation results modeling significant changes over time (mean duration of 2 years) in connectivity. MFG connectivity significantly increased by 0.264 units per year, which was lower by 0.1 units per unit PiB SUVR. *p < 0.05; **p < 0.01; ***p < 0.001

From: The effect of amyloid deposition on longitudinal resting-state functional connectivity in cognitively normal older adults

Predicting changes in MFG connectivity with memory encoding network

 

β (unstandardized)

Standard error

Intercept

− 1.532

1.976

Covariates of no interest

  

Sex (M:F)

− 0.012

0.123

Education (years)

0.015

0.018

Race (B:W)

0.032

0.253

Age (years)

0.015

0.010

Intracranial volume (cubic mm)

0.000

0.000

Predictors

 Time (years)

0.264*

0.065

  amyloid (PiB SUVR)

− 0.049

0.237

  glucose metabolism (FDG SUVR)

− 0.034

0.516

  Normalized hippocampal volume

− 13.853

61.567

  Normalized WMH volume

0.063

0.092

Interactions

  

 Time × PiB

− 0.100*

0.031

  Time × FDG

Not significant, not included

  Time × hippocampal volume

Not significant, not included

  Time × WMH volume

Not significant, not included