Sleep dysregulation, memory impairment, and CSF biomarkers during different levels of neurocognitive functioning in Alzheimer’s disease course

Table 2 Correlation matrix among 15 variables in the whole population (n = 258)

Pearson’s correlation	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
1. Sex	1
2. Age	−0.051	1
3. MMSE	− 0.060	− .209^**	1
4. T-tau	0.036	.330^**	− .488^**	1
5. P-tau	−0.019	.299^**	− .408^**	.845^**	1
6. Aβ₄₂	0.010	− .229^**	.543^**	− .515^**	− .422^**	1
7. TST	−0.085	− .141^*	.531^**	− .324^**	− .287^**	.306^**	1
8. SE	−0.062	− .224^**	.471^**	− .361^**	− .329^**	.403^**	.589^**	1
9. SL	0.078	0.066	−0.035	0.103	0.112	− 0.029	0.078	− .292^**	1
10. LREM	0.020	0.052	− .161^**	0.079	0.082	− .260^**	− .176^**	− .289^**	.145^*	1
11. N1	0.037	.178^**	− .538^**	.434^**	.351^**	− .564^**	− .397^**	− .428^**	0. .075	.247^**	1
12. N2	0.059	−0.041	−0.070	−0.077	−0.085	0.006	−0.048	0.003	−0.077	.209^**	− .326^**	1
13. N3	−0.095	−0.083	.463^**	− .333^**	− .267^**	.362^**	.323^**	.215^**	0.047	− .185^**	− .618^**	− .404^**	1
14. REM	−0.025	− .197^**	.537^**	− .315^**	− .256^**	.613^**	.420^**	.555^**	−0.096	− .513^**	− .658^**	− .263^**	.491^**	1
15. WASO	0.041	.151^*	− .202^**	.142^*	.128^*	− .264^**	− .268^**	− .847^**	.134^*	.230^**	.251^**	−0.008	−0.063	− .405^**	1
16. TIB	−0.034	0.000	.272^**	−0.115	−0.095	0.033	.698^**	− .146^*	.386^**	0.058	−0.116	−0.077	.226^**	0.039	.428^**	1
17.RAVLT-I	−0.037	− .236^**	.765^**	− .628^**	− .546^**	.802^**	.429^**	.457^**	−0.075	− .270^**	− .647^**	0.013	.454^**	.650^**	− .209^**	.156^*	1
18. RAVLT-D	−0.045	− .233^**	.658^**	− .597^**	− .505^**	.828^**	.353^**	.444^**	−0.074	− .264^**	− .589^**	0.008	.388^**	.630^**	− .238^**	0.074	.928^**	1

*p < 0.05; **p < 0.01
Abbreviations: MMSE Mini-Mental State Examination, T-tau total tau, P-tau phosphorylated tau, Aβ₄₂ β-amyloid42, RAVLT-I Immediate Recall – Rey Auditory Verbal Learning Test, RAVLT-D Differite Recall – Rey Auditory Verbal Learning Test, TST total sleep time, SE sleep efficiency, LREM REM sleep latency, N1 stage 1 of non-REM sleep, N2 stage 2 of non-REM sleep, N3 stage 3 of non-REM sleep, REM REM sleep, WASO wakefulness after sleep onset, TIB time in bed, SL sleep onset latency

ISSN: 1758-9193