Fig. 2

Dementia modeling confirmation of cholinergic lesion with 192 IgG-saporin reduces ChAT in MS/DB. a Representative histological sections showing the effect of the cholinergic lesion on MS/DB. The number of ChAT-positive cells was significantly decreased in both the SAP and SAP+FUS groups compared with that in the control group. Scale bar represents 200 μm. b Five days after sonication and c 18 days after sonication, bar graph represents ChAT-positive cells in MS/DB. Data are expressed as mean ± SE. n = 3–4 for each group. *P < 0.05, **P < 0.01, ***P < 0.001; one-way ANOVA with Tukey’s multiple comparisons test