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Table 4 Sensitivity, specificity, positive predictive value, and negative predictive value for pathways II to V, utilizing various blood biomarkers for PET scan pre-screening

From: Plasma amyloid assay as a pre-screening tool for amyloid positron emission tomography imaging in early stage Alzheimer’s disease

Pathway

II

III

IV

V

Biomarker

APOE ε4

Plasma Aβ1–42

APOE ε4 + plasma Aβ1–42

APOE ε4 + ε2 + plasma Aβ1–42

SS

0.595

0.591

0.864

0.864

SP

0.933

0.600

0.600

0.733

Accuracy

0.769

0.596

0.711

0.788

PPV

0.857

0.520

0.613

0.704

NPV

0.737

0.667

0.857

0.880

AUC

0.739

0.611

0.856

0.902

  1. Abbreviations: Aβ Amyloid β, NPV negative predictive value, PET positron emission tomography, PPV positive predictive value, SP specificity, SS sensitivity, AUC area under curve
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Alzheimer's Research & Therapy

ISSN: 1758-9193