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Table 4 Sensitivity, specificity, positive predictive value, and negative predictive value for pathways II to V, utilizing various blood biomarkers for PET scan pre-screening

From: Plasma amyloid assay as a pre-screening tool for amyloid positron emission tomography imaging in early stage Alzheimer’s disease

PathwayIIIIIIVV
BiomarkerAPOE ε4Plasma Aβ1–42APOE ε4 + plasma Aβ1–42APOE ε4 + ε2 + plasma Aβ1–42
SS0.5950.5910.8640.864
SP0.9330.6000.6000.733
Accuracy0.7690.5960.7110.788
PPV0.8570.5200.6130.704
NPV0.7370.6670.8570.880
AUC0.7390.6110.8560.902
  1. Abbreviations: Amyloid β, NPV negative predictive value, PET positron emission tomography, PPV positive predictive value, SP specificity, SS sensitivity, AUC area under curve