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Table 4 Sensitivity, specificity, positive predictive value, and negative predictive value for pathways II to V, utilizing various blood biomarkers for PET scan pre-screening

From: Plasma amyloid assay as a pre-screening tool for amyloid positron emission tomography imaging in early stage Alzheimer’s disease

Pathway II III IV V
Biomarker APOE ε4 Plasma Aβ1–42 APOE ε4 + plasma Aβ1–42 APOE ε4 + ε2 + plasma Aβ1–42
SS 0.595 0.591 0.864 0.864
SP 0.933 0.600 0.600 0.733
Accuracy 0.769 0.596 0.711 0.788
PPV 0.857 0.520 0.613 0.704
NPV 0.737 0.667 0.857 0.880
AUC 0.739 0.611 0.856 0.902
  1. Abbreviations: Amyloid β, NPV negative predictive value, PET positron emission tomography, PPV positive predictive value, SP specificity, SS sensitivity, AUC area under curve