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Table 4 Results for secondary regression model with sex, diagnosis (cognitively normal, subjective cognitive decline, or mild cognitive impairment), Aβ/Ptau status, and their interactions predicting recall omissions on the ADAS word recall task

From: Cognitively normal women with Alzheimer’s disease proteinopathy show relative preservation of memory but not of hippocampal volume

Variable

ADAS 10 Word Recall Omissions

Estimate (CI)

p

Intercept

−.986 (−2.14–4.90)

0.454

Diagnosis (1 = CN, 2 = SCD, 3 = MCI)

1.75 (1.44–2.07)

< 0.001

Age

0.03 (−0.00–0.60)

0.035

Education

−0.07 (−0.12 to − 0.03)

< 0.001

Total intracranial volume (z-scored)

0.081 (−0.12–0.28)

0.419

Sex (0 = male)

−0.40 (−1.31–0.51)

0.392

Hippocampal volume (z-scored)

− 0.517 (− 0.70 to − 0.34)

< 0.001

APOE ε4 genotype (0 = no ε4)

0.01 (− 0.33–0.35)

0.96

CSF Aβ/P-tau positivity (Aβ/P-tau+) (0 = not Aβ/P-tau+)

0.64 (− 0.77–2.04)

0.376

Aβ/P-tau+ × diagnosis

0.03 (− 0.54–0.60)

0.92

Aβ/P-tau+ × sex

− 1.50 (− 3.32–0.32)

0.108

Diagnosis × sex

−0.20 (− 0.65–0.26)

0.398

Aβ/P-tau+ × diagnosis × sex

1.03 (0.25–1.82)

0.01

  1. Note: Estimates, confidence intervals, and p values were calculated for each regression model
  2. Abbreviations: Aβ/P-tau+ amyloid beta/P-tau positive, ADAS Alzheimer’s Disease Assessment Scale, APOE apolipoprotein E, CSF cerebrospinal fluid, MMSE Mini-Mental State Examination