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Table 4 Results for secondary regression model with sex, diagnosis (cognitively normal, subjective cognitive decline, or mild cognitive impairment), Aβ/Ptau status, and their interactions predicting recall omissions on the ADAS word recall task

From: Cognitively normal women with Alzheimer’s disease proteinopathy show relative preservation of memory but not of hippocampal volume

VariableADAS 10 Word Recall Omissions
Estimate (CI)p
Intercept−.986 (−2.14–4.90)0.454
Diagnosis (1 = CN, 2 = SCD, 3 = MCI)1.75 (1.44–2.07)< 0.001
Age0.03 (−0.00–0.60)0.035
Education−0.07 (−0.12 to − 0.03)< 0.001
Total intracranial volume (z-scored)0.081 (−0.12–0.28)0.419
Sex (0 = male)−0.40 (−1.31–0.51)0.392
Hippocampal volume (z-scored)− 0.517 (− 0.70 to − 0.34)< 0.001
APOE ε4 genotype (0 = no ε4)0.01 (− 0.33–0.35)0.96
CSF Aβ/P-tau positivity (Aβ/P-tau+) (0 = not Aβ/P-tau+)0.64 (− 0.77–2.04)0.376
Aβ/P-tau+ × diagnosis0.03 (− 0.54–0.60)0.92
Aβ/P-tau+ × sex− 1.50 (− 3.32–0.32)0.108
Diagnosis × sex−0.20 (− 0.65–0.26)0.398
Aβ/P-tau+ × diagnosis × sex1.03 (0.25–1.82)0.01
  1. Note: Estimates, confidence intervals, and p values were calculated for each regression model
  2. Abbreviations: Aβ/P-tau+ amyloid beta/P-tau positive, ADAS Alzheimer’s Disease Assessment Scale, APOE apolipoprotein E, CSF cerebrospinal fluid, MMSE Mini-Mental State Examination