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Table 3 Results for regression models with sex, diagnosis (cognitively normal or symptomatic), Aβ/P-tau status, and their interactions predicting recall omissions on the ADAS word recall task and total hippocampal volume

From: Cognitively normal women with Alzheimer’s disease proteinopathy show relative preservation of memory but not of hippocampal volume

Variable

ADAS 10 Word Recall Omissions

Estimate

p

Intercept

0.56

0.704

Diagnosis (0 = CN, 1 = symptomatic)

2.51

< 0.001

Age

0.0088

0.61

Education

−0.107

< 0.001

Total intracranial volume (z-scored)

0.225

0.039

Sex (0 = male)

0.22

0.74

Hippocampal volume (z-scored)

−0.781

< 0.001

APOE ε4 Genotype (0 = no ε4)

0.049

0.79

CSF Aβ/P-tau positivity (Aβ/P-tau+) (0 = not Aβ/P-tau+)

1.97

0.10

Aβ/P-tau+ × diagnosis

−0.63

0.33

Aβ/P-tau+ × sex

−4.05

0.008

Diagnosis × sex

−0.76

0.06

Aβ/P-tau+ × diagnosis × sex

2.92

< 0.001

Variable

Total hippocampal volume

Estimate

p

Intercept

10,938

< 0.001

Diagnosis (0 = CN, 1 = symptomatic)

− 547

< 0.001

Age

−82.8

< 0.001

Education

5.00

0.64

Total intracranial volume (z-scored)

0.0019

< 0.001

Sex (0 = male)

− 166

0.59

APOE ε4 Genotype (0 = no ε4)

20.7

0.81

Aβ/P-tau+ (0 = not Aβ/P-tau+)

453

0.42

Aβ/P-tau+ × diagnosis

− 401

0.18

Aβ/P-tau+ × sex

−72.1

0.92

Diagnosis × sex

77.8

0.68

Aβ/P-tau+ × diagnosis × sex

−76.0

0.84

  1. Abbreviations: Aβ/P-tau+ amyloid beta/P-tau positivity, ADAS Alzheimer’s disease Assessment Scale, APOE apolipoprotein E, CN cognitively normal, CSF cerebrospinal fluid, MMSE Mini-Mental State Examination
  2. significant p values had been bolded (p < .05)