Skip to main content

Table 3 Results for regression models with sex, diagnosis (cognitively normal or symptomatic), Aβ/P-tau status, and their interactions predicting recall omissions on the ADAS word recall task and total hippocampal volume

From: Cognitively normal women with Alzheimer’s disease proteinopathy show relative preservation of memory but not of hippocampal volume

VariableADAS 10 Word Recall Omissions
Estimatep
Intercept0.560.704
Diagnosis (0 = CN, 1 = symptomatic)2.51< 0.001
Age0.00880.61
Education−0.107< 0.001
Total intracranial volume (z-scored)0.2250.039
Sex (0 = male)0.220.74
Hippocampal volume (z-scored)−0.781< 0.001
APOE ε4 Genotype (0 = no ε4)0.0490.79
CSF Aβ/P-tau positivity (Aβ/P-tau+) (0 = not Aβ/P-tau+)1.970.10
Aβ/P-tau+ × diagnosis−0.630.33
Aβ/P-tau+ × sex−4.050.008
Diagnosis × sex−0.760.06
Aβ/P-tau+ × diagnosis × sex2.92< 0.001
VariableTotal hippocampal volume
Estimatep
Intercept10,938< 0.001
Diagnosis (0 = CN, 1 = symptomatic)− 547< 0.001
Age−82.8< 0.001
Education5.000.64
Total intracranial volume (z-scored)0.0019< 0.001
Sex (0 = male)− 1660.59
APOE ε4 Genotype (0 = no ε4)20.70.81
Aβ/P-tau+ (0 = not Aβ/P-tau+)4530.42
Aβ/P-tau+ × diagnosis− 4010.18
Aβ/P-tau+ × sex−72.10.92
Diagnosis × sex77.80.68
Aβ/P-tau+ × diagnosis × sex−76.00.84
  1. Abbreviations: Aβ/P-tau+ amyloid beta/P-tau positivity, ADAS Alzheimer’s disease Assessment Scale, APOE apolipoprotein E, CN cognitively normal, CSF cerebrospinal fluid, MMSE Mini-Mental State Examination
  2. significant p values had been bolded (p < .05)