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Table 2 Means and standard deviations by symptomatic diagnostic group (subjective cognitive decline or mild cognitive impairment), sex, and Aβ/P-tau status for demographics; memory and global cognitive scores, hippocampal and total intracranial volumes; and number of APOE ε4 carriers

From: Cognitively normal women with Alzheimer’s disease proteinopathy show relative preservation of memory but not of hippocampal volume

 Subjective cognitive decline (SCD)Mild cognitive impairment (MCI)
MenWomenMenWomen
Aβ/P-tau+Aβ/P-tau−Aβ/P-tau+Aβ/P-tau−Aβ/P-tau+Aβ/P-tau−Aβ/P-tau+Aβ/P-tau−
(N = 34)(N = 51)(N = 25)(N = 76)(N = 74)(N = 75)(N = 63)(N = 34)
Age72.59 (5.37) a,b70.22 (5.46) a,b70.63 (4.84) a,b69.78 (5.69) a,b72.35 (5.13) a69.59 (5.74) a71.37 (4.88) a69.76 (5.52) a
Education11.71 (3.84) a13.00 (3.59) a11.60 (3.33) a11.97 (3.30) a11.62 (3.49) a10.71 (3.48) a11.44 (3.07) a10.47 (3.13) a
ADAS Delayed Word Recall Omissions (/10)4.12 (1.89)3.38 (1.89)5.06 (3.02)4.73 (2.80)6.91 (2.06) a5.92 (2.10) a7.43 (1.81) a5.24 (2.69) a
MMSE total score28.35 (1.54)28.92 (1.29)27.88 (1.88)27.74 (1.73)26.65 (1.67)27.56 (1.85)26.84 (1.79)27.62 (1.88)
Total intracranial volume1.7 × 106 (1.1 × 105)1.7 × 106 (1.3 × 105)1.5 × 106 (1.1 × 105)1.5 × 106 (1.2 × 105)1.7 × 106 (1.3 × 105)1.7 × 106 (1.4 × 105)1.5 × 106 (1.2 × 105)1.5 × 106 (1.2 × 105)
Total hippocampal volume7.2 × 103 (1.1 × 103)7.7 × 103 (1.3 × 103)6.8 × 103 (1.3 × 103)6.7 × 103 (1.1 × 103)6.7 × 103 (1.1 × 103)7.2 × 103 (1.3 × 103)6.1 × 103 (1.0 × 103)6.6 × 103 (1.2 × 103)
APOE ε4 carriers21 a14 a17 a21 a55 a20 a46 a6 a
  1. Abbreviations: Aβ/P-tau+ amyloid beta/P-tau positive, ADAS Alzheimer’s Disease Assessment Scale, APOE apolipoprotein E, MMSE Mini-Mental State Examination
  2. aDiffers by Aβ/P-tau+ within diagnostic group, p < 0.05
  3. bDiffers by sex within diagnostic group, p < 0.05
  4. Significant differences in these variables by Aβ/P-tau status and sex within each diagnostic group are indicated by superscript