Table 1 Means and standard deviations by diagnostic group (cognitively normal or symptomatic), sex, and Aβ/P-tau status for demographics; memory and global cognitive scores, hippocampal and total intracranial volumes; and number of APOE ε4 carriers
Cognitively normal (CN) | Symptomatic patients | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Men | Women | Men | Women | ||||||
Aβ/P-tau+ | Aβ/P-tau− | Aβ/P-tau+ | Aβ/P-tau− | Aβ/P-tau+ | Aβ/P-tau− | Aβ/P-tau+ | Aβ/P-tau− | ||
(N = 16) | (N = 82) | (N = 29) | (N = 123) | (N = 108) | (N = 126) | (N = 88) | (N = 110) | ||
Age | 74.38 (4.40) b | 72.40 (4.58) b | 74.38 (4.34) b | 74.03 (5.31) b | 72.43 (5.18) a,b | 69.84 (5.61) a,b | 71.12 (5.05) a,b | 69.08 (5.68) a,b | |
Education | 14.12 (4.29) | 12.17 (3.58) | 11.97 (4.23) | 12.08 (3.30) | 11.65 (3.58) | 11.63 (3.69) | 11.51 (3.31) | 12.18 (3.28) | |
ADAS Delayed Word Recall Omissions (/10) | 3.31 (2.39) | 2.12 (1.63) | 2.07 (2.17) | 1.74 (1.91) | 6.00 (2.39) | 4.90 (2.37) | 6.50 (2.40) | 3.50 (2.46) | |
MMSE total score | 28.69 (0.87) | 29.09 (0.98) | 29.17 (0.76) | 28.91 (0.99) | 27.19 (1.80) | 28.11 (1.78) | 27.1 (1.78) | 28.31 (1.57) | |
Total intracranial volume | 1.7 × 106 (1.5 × 105) | 1.7 × 106 (1.3 × 105) | 1.5 × 106 (9.7 × 104) | 1.5 × 106 (1.1 × 105) | 1.7 × 106 (1.2 × 105) | 1.7 × 106 (1.4 × 105) | 1.5 × 106 (1.2 × 105) | 1.5 × 106 (1.2 × 105) | |
Total hippocampal volume | 7.8 × 103 (1.0 × 103) | 7.7 × 103 (1.1 × 103) | 7.0 × 103 (8.9 × 102) | 7.1 × 103 (9.1 × 102) | 6.8 × 103 (1.1 × 103) | 7.4 × 103 (1.3 × 103) | 6.3 × 103 (1.1 × 103) | 7.1 × 103 (1.1 × 103) | |
APOE ε4 carriers | 12 a | 16 a | 16 a | 23 a | 76 a | 34 a | 63 a | 27 a | |