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Table 1 Means and standard deviations by diagnostic group (cognitively normal or symptomatic), sex, and Aβ/P-tau status for demographics; memory and global cognitive scores, hippocampal and total intracranial volumes; and number of APOE ε4 carriers

From: Cognitively normal women with Alzheimer’s disease proteinopathy show relative preservation of memory but not of hippocampal volume

 Cognitively normal (CN)Symptomatic patients
MenWomenMenWomen
Aβ/P-tau+Aβ/P-tau−Aβ/P-tau+Aβ/P-tau−Aβ/P-tau+Aβ/P-tau−Aβ/P-tau+Aβ/P-tau−
(N = 16)(N = 82)(N = 29)(N = 123)(N = 108)(N = 126)(N = 88)(N = 110)
Age74.38 (4.40) b72.40 (4.58) b74.38 (4.34) b74.03 (5.31) b72.43 (5.18) a,b69.84 (5.61) a,b71.12 (5.05) a,b69.08 (5.68) a,b
Education14.12 (4.29)12.17 (3.58)11.97 (4.23)12.08 (3.30)11.65 (3.58)11.63 (3.69)11.51 (3.31)12.18 (3.28)
ADAS Delayed Word Recall Omissions (/10)3.31 (2.39)2.12 (1.63)2.07 (2.17)1.74 (1.91)6.00 (2.39)4.90 (2.37)6.50 (2.40)3.50 (2.46)
MMSE total score28.69 (0.87)29.09 (0.98)29.17 (0.76)28.91 (0.99)27.19 (1.80)28.11 (1.78)27.1 (1.78)28.31 (1.57)
Total intracranial volume1.7 × 106 (1.5 × 105)1.7 × 106 (1.3 × 105)1.5 × 106 (9.7 × 104)1.5 × 106 (1.1 × 105)1.7 × 106 (1.2 × 105)1.7 × 106 (1.4 × 105)1.5 × 106 (1.2 × 105)1.5 × 106 (1.2 × 105)
Total hippocampal volume7.8 × 103 (1.0 × 103)7.7 × 103 (1.1 × 103)7.0 × 103 (8.9 × 102)7.1 × 103 (9.1 × 102)6.8 × 103 (1.1 × 103)7.4 × 103 (1.3 × 103)6.3 × 103 (1.1 × 103)7.1 × 103 (1.1 × 103)
APOE ε4 carriers12 a16 a16 a23 a76 a34 a 63 a27 a
  1. Abbreviations: Aβ/P-tau+ amyloid beta/P-tau positive, ADAS Alzheimer’s Disease Assessment Scale, APOE apolipoprotein E, MMSE Mini-Mental State Examination
  2. aDiffers by Aβ/P-tau+ within diagnostic group, p < 0.001
  3. bDiffers by sex within diagnostic group, p < 0.05
  4. Significant differences in these variables by Aβ/P-tau status and sex within each diagnostic group are indicated by superscript