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Table 5 Adjusted mean differences and 95% confidence intervals in CSF protein concentrations of the five synaptic measures between the likely tau and TDP-43 groups, and controls

From: CSF synaptic protein concentrations are raised in those with atypical Alzheimer’s disease but not frontotemporal dementia

Group comparisonNg22 (pg/ml)Ng36 (pg/ml)SNAP-25tot (pM)SNAP-25aa40 (pM)Synaptotagmin-1 (pM)
Tau vs TDP-43 group65.9 (− 14.9, 246.4)28.6 (− 22.7, 69.8)5.6 (− 6.2, 15.2)1.3 (− 0.4, 2.7)− 6.4 (− 67.8, 47.8)
Tau vs control group32.7 (− 45.3, 216.6)51.5 (− 0.7, 101.7)2.8 (− 8.8, 12.5)1.4 (− 0.5, 3.0)− 21.9 (− 79.5, 33.7)
TDP-43 vs control group− 33.2 (− 97.6, 37.8)23.0 (− 26.0, 78.5)− 2.8 (− 10.9, 6.7)0.2 (− 1.5, 1.6)− 15.4 (− 67.7, 37.5)
  1. No significant differences were seen