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Table 5 Adjusted mean differences and 95% confidence intervals in CSF protein concentrations of the five synaptic measures between the likely tau and TDP-43 groups, and controls

From: CSF synaptic protein concentrations are raised in those with atypical Alzheimer’s disease but not frontotemporal dementia

Group comparison

Ng22 (pg/ml)

Ng36 (pg/ml)

SNAP-25tot (pM)

SNAP-25aa40 (pM)

Synaptotagmin-1 (pM)

Tau vs TDP-43 group

65.9 (− 14.9, 246.4)

28.6 (− 22.7, 69.8)

5.6 (− 6.2, 15.2)

1.3 (− 0.4, 2.7)

− 6.4 (− 67.8, 47.8)

Tau vs control group

32.7 (− 45.3, 216.6)

51.5 (− 0.7, 101.7)

2.8 (− 8.8, 12.5)

1.4 (− 0.5, 3.0)

− 21.9 (− 79.5, 33.7)

TDP-43 vs control group

− 33.2 (− 97.6, 37.8)

23.0 (− 26.0, 78.5)

− 2.8 (− 10.9, 6.7)

0.2 (− 1.5, 1.6)

− 15.4 (− 67.7, 37.5)

  1. No significant differences were seen