Table 5 Diagnostic value of CSF biomarkers in the differential diagnosis between disease groups
From: CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementia
| Â | AUC | Cutoff | sens (%) | spec (%) | AUC | Cutoff | sens (%) | spec (%) |
|---|---|---|---|---|---|---|---|---|
| Â | Prion disease vs. controls | AD vs. controls | ||||||
CHIT1 | 0.746 ± 0.041 | > 1664 pg/ml | 73.3 | 62.5 | 0.701 ± 0.059 | > 1911 pg/ml | 67.5 | 65.0 |
YKL-40 | 0.919 ± 0.023 | > 184 ng/ml | 84.8 | 95.0 | 0.882 ± 0.038 | > 165 ng/ml | 82.5 | 80.0 |
GFAP | 0.687 ± 0.046 | > 0.782 ng/ml | 62.6 | 62.5 | 0.681 ± 0.060 | > 0.799 ng/ml | 67.5 | 62.5 |
NfL | 0.990 ± 0.010 | > 1458 pg/ml | 98.0 | 100.0 | 0.888 ± 0.035 | > 813 pg/ml | 80.0 | 75.0 |
t-tau | 0.987 ± 0.010 | > 388 pg/ml | 98.0 | 100.0 | 0.973 ± 0.025 | > 314 pg/ml | 97.5 | 95.0 |
| Â | FTD vs. controls | FTLD-TDP vs. FTLD-TAU | ||||||
CHIT1 | 0.688 ± 0.050 | > 1616 pg/ml | 72.9 | 62.5 | 0.727 ± 0.061 | > 2657 pg/ml | 69.7 | 68.4 |
YKL-40 | 0.777 ± 0.043 | > 156 ng/ml | 70.0 | 72.5 | 0.542 ± 0.071 | > 192 ng/ml | 54.5 | 56.8 |
GFAP | 0.706 ± 0.050 | > 0.797 ng/ml | 67.1 | 62.5 | 0.584 ± 0.069 | > 1.130 ng/ml | 57.6 | 59.5 |
NfL | 0.949 ± 0.022 | > 1037 pg/ml | 93.0 | 92.5 | 0.827 ± 0.053 | > 3040 pg/ml | 75.8 | 81.6 |
t-tau | 0.725 ± 0.048 | > 209 pg/ml | 67.1 | 67.5 | 0.731 ± 0.062 | > 253 pg/ml | 69.7 | 68.4 |
p-tau/t-tau | 0.760 ± 0.044 | < 0.175 | 67.5 | 66.3 | 0.818 ± 0.050 | < 0.141 | 76.3 | 72.7 |