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Table 5 Diagnostic value of CSF biomarkers in the differential diagnosis between disease groups

From: CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementia

 AUCCutoffsens (%)spec (%)AUCCutoffsens (%)spec (%)
 Prion disease vs. controlsAD vs. controls
CHIT10.746 ± 0.041> 1664 pg/ml73.362.50.701 ± 0.059> 1911 pg/ml67.565.0
YKL-400.919 ± 0.023> 184 ng/ml84.895.00.882 ± 0.038> 165 ng/ml82.580.0
GFAP0.687 ± 0.046> 0.782 ng/ml62.662.50.681 ± 0.060> 0.799 ng/ml67.562.5
NfL0.990 ± 0.010> 1458 pg/ml98.0100.00.888 ± 0.035> 813 pg/ml80.075.0
t-tau0.987 ± 0.010> 388 pg/ml98.0100.00.973 ± 0.025> 314 pg/ml97.595.0
 FTD vs. controlsFTLD-TDP vs. FTLD-TAU
CHIT10.688 ± 0.050> 1616 pg/ml72.962.50.727 ± 0.061> 2657 pg/ml69.768.4
YKL-400.777 ± 0.043> 156 ng/ml70.072.50.542 ± 0.071> 192 ng/ml54.556.8
GFAP0.706 ± 0.050> 0.797 ng/ml67.162.50.584 ± 0.069> 1.130 ng/ml57.659.5
NfL0.949 ± 0.022> 1037 pg/ml93.092.50.827 ± 0.053> 3040 pg/ml75.881.6
t-tau0.725 ± 0.048> 209 pg/ml67.167.50.731 ± 0.062> 253 pg/ml69.768.4
p-tau/t-tau0.760 ± 0.044< 0.17567.566.30.818 ± 0.050< 0.14176.372.7
  1. AD Alzheimer’s disease, AUC area under the curve, CHIT1 chitotriosidase 1, CJD Creutzfeldt-Jakob disease, FTD frontotemporal dementia, FTLD-TAU frontotemporal lobar degeneration with tau pathology, FTLD-TDP frontotemporal lobar degeneration with TDP43 pathology, GFAP glial fibrillary acidic protein, NfL neurofilament light protein, p-tau phosphorylated tau protein, sens sensitivity, spec specificity, t-tau total tau protein, YKL-40 chitinase-3-like protein 1