Table 3 CSF biomarkers of neuroinflammation in prion disease subtypes
From: CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementia
Subtype | Number | CHIT1 all (pg/ml), median (IQR) | CHIT1 WT + Het (pg/ml), median (IQR) | YKL-40 (ng/ml), median (IQR) | GFAP (ng/ml), median (IQR) |
|---|---|---|---|---|---|
All sCJD | 85 | 4092 (1509–8644) | 4154 (1872–8645) | 321 (222–471) | 1.115 (0.633–1.655) |
sCJD MM(V)1 | 34 | 3069 (1229–6921) | 3290 (1235–7191) | 259 (175–358) | 0.810 (0.611–1.295) |
sCJD VV2 | 26 | 5060 (2474–15,725) | 5718 (2877–30,500) | 533 (314–783) | 1.638 (0.857–2.559) |
sCJD MV2K | 20 | 5064 (2170–8532) | 5064 (2170–8532) | 321 (214–406) | 0.763 (0.352–1.230) |
sCJD MM2C | 4 | 2158 (646–6125) | 2572 | 195 (178–314) | 1.146 (0.577–1.716) |
sCJD VV1 | 1 | 38,000 | 38,000 | 455 | 0.829 |
VPSPr | 1 | 2562 | 2562 | 341 | 2.779 |
gCJD E200K | 5 | 2572 (828–4415) | 2767 | 269 (206–782) | 1.127 (0.955–2.088) |
gCJD V210I | 5 | 1820 (934–4415) | 1820 (1226–3838) | 349 (184–472) | 0.412 (0.329–1.351) |
FFI (D178N) | 3 | 16,800, 1571, 4156 | 16,800,1571, 4156 | 146, 253, 165 | 0.827, 0.415, 0.227 |
Pre-symptomatic GSS (P102L) | 1 | 8353* | 8353* | 186* | 1.114* |
Symptomatic GSS (P102L) | 2 | 18000*, 2356 | 18000*, 2356 | 297*, 450 | 1.712*, 0.418 |