CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementia

Table 1 Demographic data and CHIT1 genotype in the diagnostic groups

Diagnosis	Prion disease	AD	FTD	Controls	P
N	101	40	72	40
Age at LP (years ± SD)	67.44 ± 9.30	68.63 ± 8.16	63.99 ± 9.04	64.88 ± 9.62	0.049^a
Female (%)	46.5%	40.0%	59.7%	45%	0.230^b
Time from onset to LP (months ± SD)	4.34 ± 4.01	44.87 ± 30.08	35.69 ± 26.87	–	< 0.001^a
MMSE score (points ± SD)	–	20.22 ± 4.87	26.50 ± 3.01	–	< 0.001^c
CHIT1 genotype
N (%)	98	34	64	23
WT	58 (59.1)	19 (55.9)	44 (68.8)	12 (52.2)	0.785^b
Het	34 (34.7)	13 (38.2)	17 (26.6)	10 (43.5)
Homo	6 (6.1)	2 (5.9)	3 (4.7)	1 (4.3)

AD Alzheimer’s disease, CHIT1 chitotriosidase 1, CJD Creutzfeldt-Jakob disease, FTD frontotemporal dementia, GFAP glial fibrillary acidic protein, Het heterozygotes for CHIT1 24-bp duplication, Homo homozygotes for CHIT1 24-bp duplication, IQR interquartile range, LP lumbar puncture, MMSE Mini-Mental State Examination, N number, SD standard deviation, YKL-40 chitinase-3-like protein 1, WT wild type for CHIT1 24-bp duplication
^aKruskal-Wallis test
^bChi-square test
^cMann-Whitney U test

ISSN: 1758-9193