Skip to main content

Table 1 Demographic data and CHIT1 genotype in the diagnostic groups

From: CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementia

DiagnosisPrion diseaseADFTDControlsP
N101407240 
Age at LP (years ± SD)67.44 ± 9.3068.63 ± 8.1663.99 ± 9.0464.88 ± 9.620.049a
Female (%)46.5%40.0%59.7%45%0.230b
Time from onset to LP (months ± SD)4.34 ± 4.0144.87 ± 30.0835.69 ± 26.87< 0.001a
MMSE score (points ± SD)20.22 ± 4.8726.50 ± 3.01< 0.001c
CHIT1 genotype
N (%)98346423 
 WT58 (59.1)19 (55.9)44 (68.8)12 (52.2)0.785b
 Het34 (34.7)13 (38.2)17 (26.6)10 (43.5) 
 Homo6 (6.1)2 (5.9)3 (4.7)1 (4.3) 
  1. AD Alzheimer’s disease, CHIT1 chitotriosidase 1, CJD Creutzfeldt-Jakob disease, FTD frontotemporal dementia, GFAP glial fibrillary acidic protein, Het heterozygotes for CHIT1 24-bp duplication, Homo homozygotes for CHIT1 24-bp duplication, IQR interquartile range, LP lumbar puncture, MMSE Mini-Mental State Examination, N number, SD standard deviation, YKL-40 chitinase-3-like protein 1, WT wild type for CHIT1 24-bp duplication
  2. aKruskal-Wallis test 
  3. bChi-square test
  4. cMann-Whitney U test