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Table 4 Information gain of multivariable logistic regression models compared to univariate logistic regression including only amyloid modalities

From: PET and CSF amyloid-β status are differently predicted by patient features: information from discordant cases

  

AIC

 

AIC

 

Predictor

PET ~

CSF

PET ~

CSF + predictor

AIC difference

CSF ~

PET

CSF ~

PET + predictor

AIC difference

Total

APOE E4 positivity

580

533

47

573

531

42

CSF tau

580

508

71

573

563

10

CSF p-tau

580

481

99

573

555

17

SCD

APOE E4 positivity

142

138

4

167

152

15

CSF tau

142

132

10

167

162

5

CSF p-tau

142

132

10

167

163

4

MCI

APOE E4 positivity

104

86

18

104

100

4

CSF tau

104

74

30

104

105

− 1

CSF p-tau

104

83

21

104

106

− 2

Dementia

APOE E4 positivity

317

295

22

286

267

19

CSF tau

317

294

23

286

285

2

CSF p-tau

317

263

54

286

276

10

  1. This table illustrates the change in Akaike Information Criterion (AIC) from the bivariate models including only amyloid modalities (PET ~ CSF and CSF ~ PET) to multivariable models including also an additional predictor. AIC measures model fit and penalizes adding additional predictors. A decrease in AIC between models shows some (0–2), considerable (4–7), or strong (> 10) evidence for gain in model fit for the second model