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Table 1 Patient groups by PET/CSF amyloid status

From: PET and CSF amyloid-β status are differently predicted by patient features: information from discordant cases

 PET−CSF−PET+CSF−PET−CSF+PET+CSF+
Demographics
N (%)315 (41)32 (4)65 (8)356 (46)
 Sex, male (%)211 (67)D17 (53)41 (63)192 (54)A
 Age, years (mean (SD))62.8 (7.7)65.0 (7.7)62.4 (9.0)63.7 (7.3)
 Education (median [IQR])5 [4, 6]5 [4, 6]5 [4, 6]5 [4, 6]
Syndrome diagnosis (%)
 SCD136 (43)10 (31)20 (31)28 (8)
 MCI55 (18)8 (25)9 (14)55 (15)
 AD dementia28 (9)11 (34)17 (26)253 (71)
 Non-AD dementia96 (31)3 (9)19 (29)20 (6)
Biomarkers
 CSF-PET difference, days (mean (SD))61 (75)54 (70)74 (84)58 (67)
 CSF Aβ42, pg/mL (median [IQR])1134 [989, 1275]BCD875 [832, 959]ACD674 [625, 741]ABD615 [537, 688]ABC
 CSF tau, pg/mL (median [IQR])277 [207, 375]BD468 [324, 716]AC287 [174, 501]BD609 [403, 845]AC
 CSF p-tau, pg/mL (median [IQR])44 [35, 54]BD67 [50, 90]AC41 [28, 61]BD82 [58, 103]AC
 APOE E4 positivity (%)84 (28)BCD18 (60)A32 (52)A238 (70)A
Cognition
 MMSE (mean (SD))26 (3)BD24 (5)A25 (4)23 (4)A
 Memory z-score (mean (SD))− 1.39 (2.27)BD− 3.14 (2.73)A− 2.20 (2.96)− 3.34 (2.76)A
 Language z-score (mean (SD))− 0.65 (1.29)− 0.95 (1.48)− 1.44 (2.27)C− 1.03 (1.83)D
 Attention z-score (mean (SD))− 0.69 (1.09)D− 0.82 (1.08)− 0.98 (1.02)− 1.10 (1.21)A
 Executive z-score (mean (SD))− 1.01 (1.38)D− 1.39 (1.55)− 1.27 (1.32)− 1.53 (1.40)A
 Visuospatial z-score (mean (SD))−0.34 (1.18)D− 1.04 (1.90)− 0.90 (1.70)− 1.36 (2.40)A
MRI
 MRI-amyloid difference, days (mean (SD))16 (50)C35 (60)44 (78)AD14 (45)C
 MTA (median [IQR])0.5 [0.0, 1.0]D0.5 [0.0, 1.0]0.5 [0.0, 1.8]1.0 [0.5, 1.5]A
 PCA (median [IQR])1.0 [0.0, 1.1]D1.0 [1.0, 1.0]1.0 [0.0, 1.4]D1.0 [1.0, 2.0]AC
 Fazekas (median [IQR])1.0 [0.0, 1.0]1.0 [0.8, 1.0]1.0 [0.0, 2.0]1.0 [0.0, 1.0]
 Lacune positivity (%)14 (6)0 (0)7 (11)17 (7)
 Microbleed positivity (%)31 (13)4 (15)4 (7)54 (21)
  1. Education is staged by Verhage classification (1–7). Lacune and microbleed positivity is scored, if at least one is present. MTA medial temporal lobe atrophy scale, PCA posterior cortical atrophy scale
  2. A, B, C, and D indicate a significant difference (p < 0.05) from other groups:
  3. A—difference from PET−CSF−
  4. B—difference from PET+CSF−
  5. C—difference from PET−CSF+
  6. D—difference from PET+CSF+