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Table 1 Patient groups by PET/CSF amyloid status

From: PET and CSF amyloid-β status are differently predicted by patient features: information from discordant cases

  PET−CSF− PET+CSF− PET−CSF+ PET+CSF+
Demographics
N (%) 315 (41) 32 (4) 65 (8) 356 (46)
 Sex, male (%) 211 (67)D 17 (53) 41 (63) 192 (54)A
 Age, years (mean (SD)) 62.8 (7.7) 65.0 (7.7) 62.4 (9.0) 63.7 (7.3)
 Education (median [IQR]) 5 [4, 6] 5 [4, 6] 5 [4, 6] 5 [4, 6]
Syndrome diagnosis (%)
 SCD 136 (43) 10 (31) 20 (31) 28 (8)
 MCI 55 (18) 8 (25) 9 (14) 55 (15)
 AD dementia 28 (9) 11 (34) 17 (26) 253 (71)
 Non-AD dementia 96 (31) 3 (9) 19 (29) 20 (6)
Biomarkers
 CSF-PET difference, days (mean (SD)) 61 (75) 54 (70) 74 (84) 58 (67)
 CSF Aβ42, pg/mL (median [IQR]) 1134 [989, 1275]BCD 875 [832, 959]ACD 674 [625, 741]ABD 615 [537, 688]ABC
 CSF tau, pg/mL (median [IQR]) 277 [207, 375]BD 468 [324, 716]AC 287 [174, 501]BD 609 [403, 845]AC
 CSF p-tau, pg/mL (median [IQR]) 44 [35, 54]BD 67 [50, 90]AC 41 [28, 61]BD 82 [58, 103]AC
 APOE E4 positivity (%) 84 (28)BCD 18 (60)A 32 (52)A 238 (70)A
Cognition
 MMSE (mean (SD)) 26 (3)BD 24 (5)A 25 (4) 23 (4)A
 Memory z-score (mean (SD)) − 1.39 (2.27)BD − 3.14 (2.73)A − 2.20 (2.96) − 3.34 (2.76)A
 Language z-score (mean (SD)) − 0.65 (1.29) − 0.95 (1.48) − 1.44 (2.27)C − 1.03 (1.83)D
 Attention z-score (mean (SD)) − 0.69 (1.09)D − 0.82 (1.08) − 0.98 (1.02) − 1.10 (1.21)A
 Executive z-score (mean (SD)) − 1.01 (1.38)D − 1.39 (1.55) − 1.27 (1.32) − 1.53 (1.40)A
 Visuospatial z-score (mean (SD)) −0.34 (1.18)D − 1.04 (1.90) − 0.90 (1.70) − 1.36 (2.40)A
MRI
 MRI-amyloid difference, days (mean (SD)) 16 (50)C 35 (60) 44 (78)AD 14 (45)C
 MTA (median [IQR]) 0.5 [0.0, 1.0]D 0.5 [0.0, 1.0] 0.5 [0.0, 1.8] 1.0 [0.5, 1.5]A
 PCA (median [IQR]) 1.0 [0.0, 1.1]D 1.0 [1.0, 1.0] 1.0 [0.0, 1.4]D 1.0 [1.0, 2.0]AC
 Fazekas (median [IQR]) 1.0 [0.0, 1.0] 1.0 [0.8, 1.0] 1.0 [0.0, 2.0] 1.0 [0.0, 1.0]
 Lacune positivity (%) 14 (6) 0 (0) 7 (11) 17 (7)
 Microbleed positivity (%) 31 (13) 4 (15) 4 (7) 54 (21)
  1. Education is staged by Verhage classification (1–7). Lacune and microbleed positivity is scored, if at least one is present. MTA medial temporal lobe atrophy scale, PCA posterior cortical atrophy scale
  2. A, B, C, and D indicate a significant difference (p < 0.05) from other groups:
  3. A—difference from PET−CSF−
  4. B—difference from PET+CSF−
  5. C—difference from PET−CSF+
  6. D—difference from PET+CSF+