Skip to main content
Fig. 6 | Alzheimer's Research & Therapy

Fig. 6

From: Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of β-amyloid peptide

Fig. 6

| ZGM1 stabilizes non-β-sheet oligomers at 37 °C and affects the length and entanglement of Aβ amyloid fibrils. a Three pathways of Aβ aggregation. Low doses of ZGM1 mediate Aβ aggregation into sponge-like aggregates in a novel pathway and reduce the neurotoxicity of Aβ. b As the concentration of ZGM1 is increased, the lengths of Aβ amyloid fibrils are shortened, but they become entangled more easily. When the concentration of ZGM1 was 1% of that of Aβ42, the actual degree of entanglement of the Aβ amyloid fibrils was the largest. c Working model of the effects of different concentrations of ZGM1 on Aβ42 polymerization in vivo. A low concentration of ZGM1 promotes the aggregation of Aβ monomers into minimally toxic amyloid fibrils, improving learning cognitive impairment in APP/PS1 mice

Back to article page