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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of β-amyloid peptide

Fig. 4

| ZGM1 improves the learning and memory ability of APP/PS1 mice. a Time course of the behavioral tests. ZGM1 at 0 (T, male, n = 12), 40 (LD, male, n = 10) or 120 mg/kg per day (HD, male, n = 10) was given to 4-month-old APP/PS1 mice for 2 months by gavage, and their behavioral changes were compared with those of age-matched WT mice (W, male, n = 10). b % weight change before and after intragastric administration. c Total movement distance in the open field for the W, T, LZ, and HZ groups. P = 0.00072. d Time spent in the closed arms of an elevated plus maze. P = 0.0025. e % time spent in exploring new objects in the novel object recognition test; from left to right: P = 0.0040, 0.033, 0.0044. f Hidden platform test in the Morris water maze (for significance, see Additional file 1: Table S2). g Time spent in the platform quadrant in the probe test, P = 0.022, 0.014. h The target zone frequency in the probe test, p = 0.0031, 0.00061, 0.0057. i Swim speeds in the probe test. The error bars represent the S.E.M. One-way analysis of variance was performed (*P < 0.05, **P < 0.01, ***P < 0.001; n/s were not significant)

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