|
MMSE total score
|
MR-DBP (n = 25)
|
MR-DBA (n = 21)
|
SR (n = 19)
|
Total (n = 64)
|
MR-DBP (n = 15)
|
MR-DBA (n = 11)
|
SR (n = 12)
|
Total (n = 38)
|
|
Baseline value, mean (SD)
|
21.56 (4.52)
|
19.29 (5.03)
|
18.84 (4.83)
|
20.07 (4.86)
|
22.31 (5.03)
|
21.55 (4.18)
|
19.58 (4.76)
|
21.26 (4.74)
|
|
Value at visit, mean (SD)
|
18.36 (5.08)
|
15.80 (5.99)
|
16.89 (6.60)
|
17.13 (5.85)
|
17.20 (7.16)
|
15.36 (7.26)
|
15.00 (8.26)
|
15.97 (7.41)
|
|
Change from baseline, mean (SD)
|
− 3.16 (2.81)
|
− 3.45 (3.63)
|
− 1.95 (3.34)
|
− 2.89 (3.25)
|
− 5.20 (4.39)
|
− 6.18 (5.34)
|
− 4.58 (5.26)
|
− 5.29 (4.87)
|
|
OLE week 52 change from baseline, mean (SD)
|
NA
|
NA
|
NA
|
NA
|
− 2.93 (2.52)
|
− 4.73 (3.82)
|
− 2.25 (3.62)
|
− 3.24 (3.36)
|
|
ADAS-Cog 11 score
|
MR-DBP (n = 24)
|
MR-DBA (n = 19)
|
SR (n = 19)
|
Total (n = 62)
|
MR-DBP (n = 14)
|
MR-DBA (n = 11)
|
SR (n = 10)
|
Total (n = 35)
|
|
Baseline value, mean (SD)
|
20.22 (8.21)
|
22.92 (10.83)
|
22.88 (7.92)
|
21.82 (9.00)
|
20.88 (10.20)
|
19.18 (10.03)
|
21.50 (9.21)
|
20.59 (9.64)
|
|
Value at visit, mean (SD)
|
24.39 (9.94)
|
28.72 (14.43)
|
29.61 (12.06)
|
27.32 (12.14)
|
28.48 (15.49)
|
31.03 (16.61)
|
26.63 (8.98)
|
28.75 (14.04)
|
|
Change from baseline, mean (SD)
|
4.28 (7.87)
|
5.82 (6.44)
|
6.74 (8.38)
|
5.51 (7.58)
|
8.17 (13.21)
|
11.85 (10.20)
|
7.87 (8.28)
|
9.24 (10.89)
|
|
OLE week 52 change from baseline, mean (SD)a
|
NA
|
NA
|
NA
|
NA
|
1.67 (7.09)
|
6.67 (7.78)
|
6.19 (9.27)
|
4.62 (8.17)
|
|
CDR-SB score
|
MR-DBP (n = 24)
|
MR-DBA (n = 19)
|
SR (n = 19)
|
Total (n = 62)
|
MR-DBP (n = 16)
|
MR-DBA (n = 11)
|
SR (n = 12)
|
Total (n = 39)
|
|
Baseline value, mean (SD)
|
5.04 (2.16)
|
5.14 (2.49)
|
5.84 (1.72)
|
5.30 (2.15)
|
4.28 (1.75)
|
4.36 (2.18)
|
5.25 (2.37)
|
4.60 (2.07)
|
|
Value at visit, mean (SD)
|
7.38 (3.02)
|
7.50 (4.21)
|
7.42 (2.84)
|
7.43 (3.32)
|
7.06 (3.73)
|
7.91 (5.75)
|
8.29 (4.29)
|
7.68 (4.45)
|
|
Change from baseline, mean (SD)
|
2.08 (2.37)
|
2.55 (2.05)
|
1.58 (1.73)
|
2.07 (2.10)
|
2.78 (2.85)
|
3.55 (3.90)
|
3.04 (2.89)
|
3.08 (3.12)
|
|
OLE week 52 change from baseline, mean (SD)b
|
NA
|
NA
|
NA
|
NA
|
1.39 (1.53)
|
1.55 (1.74)
|
2.00 (1.72)
|
1.64 (1.63)
|
