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Table 3 Mean change in clinical endpoints from OLE baseline to OLE week 52 and OLE week 104

From: Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer’s disease: a PET substudy interim analysis

  OLE week 52 OLE week 104
MMSE total score MR-DBP (n = 25) MR-DBA (n = 21) SR (n = 19) Total (n = 64) MR-DBP (n = 15) MR-DBA (n = 11) SR (n = 12) Total (n = 38)
 Baseline value, mean (SD) 21.56 (4.52) 19.29 (5.03) 18.84 (4.83) 20.07 (4.86) 22.31 (5.03) 21.55 (4.18) 19.58 (4.76) 21.26 (4.74)
 Value at visit, mean (SD) 18.36 (5.08) 15.80 (5.99) 16.89 (6.60) 17.13 (5.85) 17.20 (7.16) 15.36 (7.26) 15.00 (8.26) 15.97 (7.41)
 Change from baseline, mean (SD) − 3.16 (2.81) − 3.45 (3.63) − 1.95 (3.34) − 2.89 (3.25) − 5.20 (4.39) − 6.18 (5.34) − 4.58 (5.26) − 5.29 (4.87)
 OLE week 52 change from baseline, mean (SD) NA NA NA NA − 2.93 (2.52) − 4.73 (3.82) − 2.25 (3.62) − 3.24 (3.36)
ADAS-Cog 11 score MR-DBP (n = 24) MR-DBA (n = 19) SR (n = 19) Total (n = 62) MR-DBP (n = 14) MR-DBA (n = 11) SR (n = 10) Total (n = 35)
 Baseline value, mean (SD) 20.22 (8.21) 22.92 (10.83) 22.88 (7.92) 21.82 (9.00) 20.88 (10.20) 19.18 (10.03) 21.50 (9.21) 20.59 (9.64)
 Value at visit, mean (SD) 24.39 (9.94) 28.72 (14.43) 29.61 (12.06) 27.32 (12.14) 28.48 (15.49) 31.03 (16.61) 26.63 (8.98) 28.75 (14.04)
 Change from baseline, mean (SD) 4.28 (7.87) 5.82 (6.44) 6.74 (8.38) 5.51 (7.58) 8.17 (13.21) 11.85 (10.20) 7.87 (8.28) 9.24 (10.89)
 OLE week 52 change from baseline, mean (SD)a NA NA NA NA 1.67 (7.09) 6.67 (7.78) 6.19 (9.27) 4.62 (8.17)
CDR-SB score MR-DBP (n = 24) MR-DBA (n = 19) SR (n = 19) Total (n = 62) MR-DBP (n = 16) MR-DBA (n = 11) SR (n = 12) Total (n = 39)
 Baseline value, mean (SD) 5.04 (2.16) 5.14 (2.49) 5.84 (1.72) 5.30 (2.15) 4.28 (1.75) 4.36 (2.18) 5.25 (2.37) 4.60 (2.07)
 Value at visit, mean (SD) 7.38 (3.02) 7.50 (4.21) 7.42 (2.84) 7.43 (3.32) 7.06 (3.73) 7.91 (5.75) 8.29 (4.29) 7.68 (4.45)
 Change from baseline, mean (SD) 2.08 (2.37) 2.55 (2.05) 1.58 (1.73) 2.07 (2.10) 2.78 (2.85) 3.55 (3.90) 3.04 (2.89) 3.08 (3.12)
 OLE week 52 change from baseline, mean (SD)b NA NA NA NA 1.39 (1.53) 1.55 (1.74) 2.00 (1.72) 1.64 (1.63)
  1. an = 12 in SR and total n = 37 at OLE week 104
  2. bn = 14 in MR-DBP and total n = 36 at OLE week 104