Table 3 Mean change in clinical endpoints from OLE baseline to OLE week 52 and OLE week 104

MMSE total score

MR-DBP (n = 25)

MR-DBA (n = 21)

SR (n = 19)

Total (n = 64)

MR-DBP (n = 15)

MR-DBA (n = 11)

SR (n = 12)

Total (n = 38)

 Baseline value, mean (SD)

21.56 (4.52)

19.29 (5.03)

18.84 (4.83)

20.07 (4.86)

22.31 (5.03)

21.55 (4.18)

19.58 (4.76)

21.26 (4.74)

 Value at visit, mean (SD)

18.36 (5.08)

15.80 (5.99)

16.89 (6.60)

17.13 (5.85)

17.20 (7.16)

15.36 (7.26)

15.00 (8.26)

15.97 (7.41)

 Change from baseline, mean (SD)

− 3.16 (2.81)

− 3.45 (3.63)

− 1.95 (3.34)

− 2.89 (3.25)

− 5.20 (4.39)

− 6.18 (5.34)

− 4.58 (5.26)

− 5.29 (4.87)

 OLE week 52 change from baseline, mean (SD)

NA

NA

NA

NA

− 2.93 (2.52)

− 4.73 (3.82)

− 2.25 (3.62)

− 3.24 (3.36)

ADAS-Cog 11 score

MR-DBP (n = 24)

MR-DBA (n = 19)

SR (n = 19)

Total (n = 62)

MR-DBP (n = 14)

MR-DBA (n = 11)

SR (n = 10)

Total (n = 35)

 Baseline value, mean (SD)

20.22 (8.21)

22.92 (10.83)

22.88 (7.92)

21.82 (9.00)

20.88 (10.20)

19.18 (10.03)

21.50 (9.21)

20.59 (9.64)

 Value at visit, mean (SD)

24.39 (9.94)

28.72 (14.43)

29.61 (12.06)

27.32 (12.14)

28.48 (15.49)

31.03 (16.61)

26.63 (8.98)

28.75 (14.04)

 Change from baseline, mean (SD)

4.28 (7.87)

5.82 (6.44)

6.74 (8.38)

5.51 (7.58)

8.17 (13.21)

11.85 (10.20)

7.87 (8.28)

9.24 (10.89)

 OLE week 52 change from baseline, mean (SD)^a

NA

NA

NA

NA

1.67 (7.09)

6.67 (7.78)

6.19 (9.27)

4.62 (8.17)

CDR-SB score

MR-DBP (n = 24)

MR-DBA (n = 19)

SR (n = 19)

Total (n = 62)

MR-DBP (n = 16)

MR-DBA (n = 11)

SR (n = 12)

Total (n = 39)

 Baseline value, mean (SD)

5.04 (2.16)

5.14 (2.49)

5.84 (1.72)

5.30 (2.15)

4.28 (1.75)

4.36 (2.18)

5.25 (2.37)

4.60 (2.07)

 Value at visit, mean (SD)

7.38 (3.02)

7.50 (4.21)

7.42 (2.84)

7.43 (3.32)

7.06 (3.73)

7.91 (5.75)

8.29 (4.29)

7.68 (4.45)

 Change from baseline, mean (SD)

2.08 (2.37)

2.55 (2.05)

1.58 (1.73)

2.07 (2.10)

2.78 (2.85)

3.55 (3.90)

3.04 (2.89)

3.08 (3.12)

 OLE week 52 change from baseline, mean (SD)^b

NA

NA

NA

NA

1.39 (1.53)

1.55 (1.74)

2.00 (1.72)

1.64 (1.63)