Fig. 3

Association of PET and clinical results. a, d, g Regression analysis of CDR-SB, ADAS-Cog 11, and MMSE, respectively, shows directional slowing of clinical decline with increasing amyloid reduction. b, e, h Change in CDR-SB, ADAS-Cog 11, and MMSE for week 104 completers stratified by patients with high and low amyloid reduction at week 104 also shows directional slowing of clinical decline in the group with higher amyloid reduction. c, f, i Stratification of patients by amyloid reduction at the earlier week 52 time point shows increased clinical benefit in the high PET reduction group, suggesting a temporal lag between amyloid reduction and clinical benefit