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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain

Fig. 2

Gene co-expression network modules—correlation to APOE genotype and GO enrichment. WGCNA was applied to determine the correlation of module eigengenes (ME) to APOE allele combinations. a The relationship table shows the correlation between the module eigengene (rows) and genotype (columns) with Pearson correlation values and p values in parentheses. Red denotes a positive, and blue denotes a negative correlation. b Top GO terms (10 or less) generated from the genes associated with modules significantly impacted by APOE genotype (Benjamini correction for multiple comparisons, shown in parentheses). c Module membership (MM) vs gene significance (GS) plots for all genes within a given module. Genes above 0.8 MM and 0.2 GS are identified as hub genes, with genes of interest labeled on the plots. d Heatmaps of genes within modules’ z-scores with values ranging from 7 (red, above average) to − 7 (blue, below average). e Whisker plots of the average z-score within a module for each sample; min and max values are indicated with tails; the numbers of transcriptomes of each genotype are as on Table 1

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