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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain

Fig. 1

APOE genotype is differentially associated with brain transcriptome. RNA-seq datasets of APOEε2/c (N = 8), APOEε3/3 (N = 12), and APOEε4/c (N = 22) samples were analyzed using edgeR. a, b Volcano plots representing the differentially expressed transcripts, colored in blue (downregulated) and red (upregulated) at FDR < 0.05. c Venn diagram with expanded GO terms generated from the genes that are upregulated in APOEε2/c vs APOEε4/c and APOEε2/c vs APOEε3/3. Shown are the number of genes that are upregulated in both comparisons (3405, white), genes uniquely upregulated in APOEε2/c vs APOEε4/c comparison (803, bright red), and genes uniquely upregulated in APOEε2/c vs APOEε3/3 (269, coral). d Venn diagram showing the number of genes downregulated in both comparisons (3094, white), uniquely downregulated in APOEε2/c vs APOEε4/c comparison (814, dark blue), and genes uniquely downregulated in APOEε2/c vs APOEε3/3 (288, light blue), as well as the associated GO terms for each group. Next to the Venn diagrams are the lists of the GO terms generated by DAVID using unique and common genes separately for each comparison

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