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Table 6 Harrell C statistic and model performance in prediction of any dementia/AD dementia

From: Progression to dementia in memory clinic patients with mild cognitive impairment and normal β-amyloid

Categories of predictors N Prediction model Dementia AD dementia
Harrell C
Basic model vs. CSF biomarkers 234 Age, RAVLT (basic) 0.69 0.69
Age, RAVLT, Aβ42 0.73 0.75
Age, RAVLT, Aβ42, p-tau 0.75 0.78
Age, RAVLT, Aβ42/p-tau 0.74 0.78
Age, RAVLT, Aβ42, t-tau 0.76 0.81
Age, RAVLT, Aβ42/t-tau 0.76 0.81
Age, RAVLT, Aβ42, p-tau, t-tau 0.78 0.83
Basic model vs. MTA 171 Age, RAVLT (basic) 0.71 0.72
Age, RAVLT, MTA 0.71 0.72
Basic model vs. APOE ε4 genotype 133 Age, RAVLT (basic) 0.68 0.68
Age, RAVLT, APOE 0.72 0.72
Basic model vs. SBP 182 Age, RAVLT (basic) 0.69 0.71
Age, RAVLT, SBP 0.70 0.71
Basic model vs. BMI 141 Age, RAVLT (basic) 0.72 0.71
Age, RAVLT, BMI 0.74 0.74
Basic model vs. depressive symptoms 183 Age, RAVLT (basic) 0.69 0.72
Age, RAVLT, Cornell score 0.70 0.74
  1. Predictive performance of the prediction models was explored using the Harrell C statistic (0.5 indicates no predictive value, whereas 1.0 indicates complete prediction, on a scale from 0 to 1). Comparisons of model performance were conducted between models including the same number of patients: basic model (age, RAVLT delayed recall score) and models expanded with additional predictors. AD Alzheimer’s disease, APOE apolipoprotein E, Aβ42 β-amyloid 1–42, BMI body mass index; CSF cerebrospinal fluid, MTA medial temporal lobe atrophy, visual rating, p-tau tau phosphorylated at threonine 181, RAVLT Rey Auditory Verbal Learning Test (delayed recall), SBP systolic blood pressure, t-tau total tau