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Table 3 Association of CSF biomarkers with the risk of progression to any dementia/AD dementia (patients with CSF Aβ42 > 696 pg/ml)

From: Progression to dementia in memory clinic patients with mild cognitive impairment and normal β-amyloid

CSF biomarker Progression to any dementia, HR (95% CI) Progression to AD dementia, HR (95% CI)
Aβ42 0.58 (0.39–0.87) 0.55 (0.33–0.93)
t-tau 2.36 (1.64–3.38) 4.33 (2.52–7.44)
p-tau 1.43 (1.04–1.96) 1.99 (1.28–3.08)
Aβ42/t-tau 0.38 (0.25–0.56) 0.21 (0.11–0.38)
Aβ42/p-tau 0.55 (0.39–0.79) 0.37 (0.22–0.62)
  1. HR (hazard ratios) (95% CI) per 1 SD increase in CSF biomarkers are shown from Cox proportional hazard models with age as time scale. Models were adjusted for sex, education, and baseline MMSE score. AD Alzheimer’s disease, Aβ42 β-amyloid 1–42, CSF cerebrospinal fluid, p-tau tau phosphorylated at threonine 181, t-tau total tau