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Table 3 Association of CSF biomarkers with the risk of progression to any dementia/AD dementia (patients with CSF Aβ42 > 696 pg/ml)

From: Progression to dementia in memory clinic patients with mild cognitive impairment and normal β-amyloid

CSF biomarker

Progression to any dementia, HR (95% CI)

Progression to AD dementia, HR (95% CI)

Aβ42

0.58 (0.39–0.87)

0.55 (0.33–0.93)

t-tau

2.36 (1.64–3.38)

4.33 (2.52–7.44)

p-tau

1.43 (1.04–1.96)

1.99 (1.28–3.08)

Aβ42/t-tau

0.38 (0.25–0.56)

0.21 (0.11–0.38)

Aβ42/p-tau

0.55 (0.39–0.79)

0.37 (0.22–0.62)

  1. HR (hazard ratios) (95% CI) per 1 SD increase in CSF biomarkers are shown from Cox proportional hazard models with age as time scale. Models were adjusted for sex, education, and baseline MMSE score. AD Alzheimer’s disease, Aβ42 β-amyloid 1–42, CSF cerebrospinal fluid, p-tau tau phosphorylated at threonine 181, t-tau total tau