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Table 2 Association of CSF biomarkers with the risk of progression to any dementia/AD dementia

From: Progression to dementia in memory clinic patients with mild cognitive impairment and normal β-amyloid

CSF biomarker Progression to any dementia, HR (95% CI) Progression to AD dementia, HR (95% CI)
Aβ42 0.65 (0.52–0.81) 0.55 (0.42–0.72)
t-tau 2.16 (1.70–2.74) 3.28 (2.42–4.46)
p-tau 1.53 (1.25–1.89) 1.99 (1.55–2.56)
Aβ42/t-tau 0.45 (0.35–0.57) 0.28 (0.20–0.40)
Aβ42/p-tau 0.56 (0.45–0.70) 0.41 (0.31–0.54)
  1. HR (hazard ratios) (95% CI) per 1 SD increase in CSF biomarkers are shown from Cox proportional hazard models with age as time scale. Models were adjusted for sex, education, and baseline MMSE score. AD Alzheimer’s disease, Aβ42 β-amyloid 1–42, CSF cerebrospinal fluid, p-tau tau phosphorylated at threonine 181, t-tau total tau