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Table 2 Association of CSF biomarkers with the risk of progression to any dementia/AD dementia

From: Progression to dementia in memory clinic patients with mild cognitive impairment and normal β-amyloid

CSF biomarker

Progression to any dementia, HR (95% CI)

Progression to AD dementia, HR (95% CI)

Aβ42

0.65 (0.52–0.81)

0.55 (0.42–0.72)

t-tau

2.16 (1.70–2.74)

3.28 (2.42–4.46)

p-tau

1.53 (1.25–1.89)

1.99 (1.55–2.56)

Aβ42/t-tau

0.45 (0.35–0.57)

0.28 (0.20–0.40)

Aβ42/p-tau

0.56 (0.45–0.70)

0.41 (0.31–0.54)

  1. HR (hazard ratios) (95% CI) per 1 SD increase in CSF biomarkers are shown from Cox proportional hazard models with age as time scale. Models were adjusted for sex, education, and baseline MMSE score. AD Alzheimer’s disease, Aβ42 β-amyloid 1–42, CSF cerebrospinal fluid, p-tau tau phosphorylated at threonine 181, t-tau total tau
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Alzheimer's Research & Therapy

ISSN: 1758-9193