Skip to main content

Table 1 Association and performance evaluation of DC-AD, DC-FTD, DC-DLB, and DC-other of each assessment section in predicting the corresponding “gold-standard” diagnosis

From: Transcranial magnetic stimulation and amyloid markers in mild cognitive impairment: impact on diagnostic confidence and diagnostic accuracy

Assessment stepsAUC (95%CI)OR (95%CI)p values*
Diagnosis of MCI-AD
 1. Clinical work-up0.706 (0.637–0.775)1.04 (1.02–1.05)
 2. Clinical work-up PLUS TMS0.879 (0.809–0.950)1.07 (1.05–1.10)1 vs. 2, p < 0.001
 3. Clinical work-up PLUS amyloid markers0.981 (0.953–1)1.14 (1.09–1.22)1 vs. 3, p < 0.001; 2 vs. 3, p < 0.010
 4. Clinical work-up PLUS TMS PLUS amyloid markers0.975 (0.946–1)1.10 (1.07–1.16)4 vs. 1, p < 0.001; 4 vs. 2, p < 0.001
 5. Clinical work-up PLUS amyloid markers PLUS TMS0.995 (0.986–1)1.15 (1.09–1.38)5 vs. 1, p < 0.001; 5 vs. 2, p < 0.001
Diagnosis of MCI-FTD
 1. Clinical work-up0.796 (0.728–0.864)1.05 (1.03–1.06)
 2. Clinical work-up PLUS TMS0.913 (0.831–0.995)1.08 (1.06–1.12)1 vs. 2, p = 0.032
 3. Clinical work-up PLUS amyloid markers0.910 (0.840–0.979)1.07 (1.05–1.10)3 vs. 1, p = 0.022
 4. Clinical work-up PLUS TMS PLUS amyloid markers0.940 (0.868–1)1.10 (1.06–1.16)4 vs. 1, p = 0.005
 5. Clinical work-up PLUS amyloid markers PLUS TMS0.910 (0.840–0.979)1.10 (1.07–1.14)5 vs. 1, p = 0.022
Diagnosis of MCI-DLB
 1. Clinical work-up0.946 (0.907–0.946)1.08 (1.06–1.11)
 2. Clinical work-up PLUS TMS0.925 (0.836–1)1.07 (1.04–1.10)
 3. Clinical work-up PLUS amyloid markers0.983 (0.951–1)1.08 (1.04–1.16)
 4. Clinical work-up PLUS TMS PLUS amyloid markers0.925 (0.836–1)1.07 (1.05–1.11)
 5. Clinical work-up PLUS amyloid markers PLUS TMS0.998 (0.991–1)1.33 (1.06–1.50)
Diagnosis of MCI-other
 1. Clinical work-up0.752 (0.652–0.848)1.04 (1.02–1.06)
 2. Clinical work-up PLUS TMS0.889 (0.772–1)1.08 (1.05–1.12)
 3. Clinical work-up PLUS amyloid markers0.844 (0.729–0.959)1.06 (1.04–1.08)
 4. Clinical work-up PLUS TMS PLUS amyloid markers0.986 (0.965–1)1.09 (1.06–1.15)4 vs. 1, p < 0.001
 5. Clinical work-up PLUS amyloid markers PLUS TMS0.957 (0.895–1)1.09 (1.06–1.13)5 vs. 1, p < 0.001
  1. Association was evaluated by odds ratio (OR) of logistic regression models; the performance was evaluated through AUC values of the receiver operating characteristic (ROC) curves
  2. DC diagnostic confidence, MCI-AD mild cognitive impairment due to Alzheimer disease, MCI-FTD mild cognitive impairment due to frontotemporal dementia, MCI-DLB mild cognitive impairment due to dementia with Lewy bodies, MCI-other mild cognitive impairment due to other conditions, AUC area under the curve, CI confidence interval, TMS transcranial magnetic stimulation
  3. *AUC comparisons: p value of significantly different AUC