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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer’s disease

Fig. 4

Loss of EphA4 does not alter hippocampal plaque load in APPPS1 mice. a Representative images of a Thioflavin S staining to determine hippocampal plaque load in AD and AD;EphA4-KO mice at 10–11 months of age. TO-PRO3 was used to stain cell nuclei. Quantification of the number of plaques/mm2 (b) and the percentage of the hippocampus positive for ThioS (c) in AD versus AD;EphA4-KO mice (unpaired t test, n = 10–13 mice/group). d Quantification of the plaque size distribution (in μm2) in the hippocampus of AD and AD;EphA4-KO mice (two-way RM ANOVA, n = 10–13 mice/group). Quantification of the levels of TBS-soluble (e) and GuHCl-soluble (f) Aβ40 and Aβ42 levels (unpaired t test, n = 11 mice/group). g Quantification of the Aβ42/Aβ40 ratio in TBS-soluble and GuHCl-soluble extracts (unpaired t test, n = 11 mice/group). If no asterisk is shown in the graph, this implies no significance. Scale bar = 100 μm. Abbreviations: ROI region of interest, ThioS Thioflavin S

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