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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer’s disease

Fig. 2

EphA4 loss ameliorates social memory in APPPS1 mice. At 9 months of age, mice were subjected to different cognitive tests to assess memory performance. Escape latency over 10 training days (a) and time spent in the target quadrant in probe trial 1 (b) and probe trial 2 (c) during the MWM test (two-way RM ANOVA and two-way ANOVA with Tukey’s multiple comparison test, and unpaired t test to compare to chance level). Sniffing time to the empty cage versus the novel mouse and preference ratio (df) in the sociability trial (unpaired t test or Mann-Whitney U test and unpaired t test compared to chance level, respectively). Sniffing time to the familiar versus the novel mouse and recognition ratio (gi) in the social memory trial of the SPSN test (unpaired t test or Mann-Whitney U test and unpaired t test compared to chance level, respectively). Total distance crossed (j) and time spent in the small periphery (k) and in the center (l) of the open field exploration test (two-way ANOVA with Tukey’s multiple comparison test). N = 22–28 mice/group. In panels b, c, and j, significant group effects (AD versus non-AD) are indicated as follows: **p ≤ 0.01, ****p ≤ 0.0001. In panels e and h, significant effects between social subjects (novel mouse versus empty or familiar mouse) are indicated as follows: *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001. Performance above chance levels (panels b, c, f, and i) are indicated as follows: +p ≤ 0.05, ++p ≤ 0.01, ++++p ≤ 0.0001. If no asterisk or plus sign is shown in the graph, this implies no significance. Abbreviations: MWM Morris water maze, SPSN sociability/preference for social novelty

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