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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ

Fig. 4

In vivo-dosed crenezumab binds to the mossy fibers in PS2APP mice. In vivo-dosed crenezumab, but not control IgG (anti-gD IgG4), dose-dependently binds to the mossy fiber axons in the hippocampus of PS2APP mice. Representative epifluorescent images of mossy fiber binding by crenezumab in PS2APP mice (a). Quantification of mossy fiber binding integrated density (IntDen) found a significant treatment effect (b) (ANOVA: F4,19 = 50.10, p < 0.0001). ANOVA followed by Tukey’s multiple comparison test: *p < 0.05, ***p < 0.001, ****p < 0.0001 as indicated or to control IgG (anti-gD)

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Alzheimer's Research & Therapy

ISSN: 1758-9193