Fig. 3

In vivo-dosed crenezumab does not bind to vascular amyloid in PS2APP mice. Representative confocal × 40 images (z-stack maximum projection) of parenchymal amyloid plaques (arrow) and vascular amyloid (arrowhead) stained with methoxy-X04 (a, c, blue). Note the selective staining of in vivo-dosed crenezumab (200 mg/kg, i.v.) (b, c, red) to the peri-plaque region and the absence from the vascular amyloid. Scale bar, 100 μm