TY - JOUR AU - Bortolotti, Daria AU - Gentili, Valentina AU - Rotola, Antonella AU - Caselli, Elisabetta AU - Rizzo, Roberta PY - 2019 DA - 2019/12/12 TI - HHV-6A infection induces amyloid-beta expression and activation of microglial cells JO - Alzheimer's Research & Therapy SP - 104 VL - 11 IS - 1 AB - The control of viral infections in the brain involves the activation of microglial cells, the macrophages of the brain that are constantly surveying the central nervous system, and the production of amyloid-beta (Aβ) as an anti-microbial molecule. Recent findings suggest a possible implication of HHV-6A in AD. We evaluated the effect of HHV-6A infection on microglial cell expression Aβ and the activation status, determined by TREM2, ApoE, cytokines, and tau expression. SN - 1758-9193 UR - https://doi.org/10.1186/s13195-019-0552-6 DO - 10.1186/s13195-019-0552-6 ID - Bortolotti2019 ER -