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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Age-dependent emergence of neurophysiological and behavioral abnormalities in progranulin-deficient mice

Fig. 3

Deficits in feedforward inhibitory signaling to the cortical neurons in progranulin-deficient mice. Paired-pulse inhibition showing the ratio of the second to the first EFPs using 25-, 50-, 100-, 150-, and 200-ms ISIs. a No significant differences in PPRs among the genotypes in 3 months. b, c PPR were significantly lower in both heterozygotes (Grn+/−) and homozygotes (Grn−/−) compared to WT using 25-ms ISI; meanwhile, there were no significant differences among the genotypes in the 50–200-ms ISI range. Data are expressed as the mean ± S.E.M. *Significant difference between heterozygotes and WT; #Significant difference between homozygote and WT. Differences in PPRs were considered significant when p < 0.05

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