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Table 4 Association between midlife physical activity and incident dementia in the MDCS cohort

From: Midlife physical activity is associated with lower incidence of vascular dementia but not Alzheimer’s disease

  All-cause dementia p Vascular dementia p Alzheimer’s dementia p
  HR (95% CI) HR (95% CI) HR (95% CI)
Physical activity
 Model 1 1373 events   300 events   832 events  
  Low (reference) 1   1   1  
  Intermediate 0.99 (0.87–1.12) 0.84 0.87 (0.66–1.14) 0.30 1.01 (0.85–1.19) 0.95
  High 0.90 (0.79–1.02) 0.11 0.63 (0.48–0.84) 0.002 1.04 (0.88–1.23) 0.64
 Model 2 1341 events   293 events   815 events  
  Low (reference) 1   1   1  
  Intermediate 0.97 (0.85–1.11) 0.68 0.88 (0.67–1.16) 0.36 0.98 (0.82–1.16) 0.79
  High 0.90 (0.79–1.03) 0.11 0.65 (0.49–0.87) 0.003 1.03 (0.87–1.22) 0.75
Excluding dementia cases < 5 years
 Model 1 1204 events   270 events   714 events  
  Low (reference) 1   1   1  
  Intermediate 1.02 (0.89–1.18) 0.75 0.92 (0.69–1.22) 0.55 1.06 (0.88–1.28) 0.54
  High 0.95 (0.83–1.09) 0.47 0.65 (0.48–0.88) 0.005 1.14 (0.95–1.37) 0.16
 Model 2 1172 events   263 events   697 events  
  Low (reference) 1   1   1  
  Intermediate 1.01 (0.88–1.17) 0.85 0.93 (0.70–1.24) 0.63 1.04 (0.86–1.25) 0.71
  High 0.96 (0.83–1.10) 0.53 0.66 (0.49–0.90) 0.008 1.14 (0.95–1.37) 0.16
  1. Association between midlife physical activity and incident dementia in the MDCS cohort, based on self-reported physical activity at two different occasions in midlife categorized as low, intermediate, or high activity group. Cox regression models showing hazard ratio (HR) with 95% confidence interval (CI) per physical activity group for risk of all-cause dementia, vascular dementia, or Alzheimer’s dementia, respectively. Number of events per model is presented for transparency, since we used complete case analyses. Model 1 adjusted for age, sex, and education. Model 2 adjusted for age, sex, education, smoking, systolic blood pressure, body mass index, alcohol consumption, diabetes, cardiovascular disease, blood pressure-lowering medication, lipid-lowering medication, and physically heavy work