Table 3 Characteristics of the MDCS population at baseline investigation (1991–1996)
All | Low physical activity group | Intermediate physical activity group | High physical activity group | |
|---|---|---|---|---|
n = 20,639 | n = 6882 | n = 6882 | n = 6875 | |
Characteristics at baseline | Median (IQR) or n (%) | Median (IQR) or n (%) | Median (IQR) or n (%) | Median (IQR) or n (%) |
Age at baseline, years | 57.5 (51.0–63.8) | 57.0 (50.9–63.7) | 57.1 (50.8–63.4) | 58.3 (51.6–64.2)*** |
Women | 12,460 (60) | 4205 (61) | 4335 (63)* | 3920 (57)*** |
Education | ||||
Primary/elementary school (≤ 8 years) | 8159 (40) | 3041 (44) | 2515 (37)*** | 2603 (38)*** |
Secondary school/high school (9–12 years) | 7449 (36) | 2387 (35) | 2568 (37) | 2494 (36) |
Higher education/university (≥ 13 years) | 5001 (24) | 1443 (21) | 1793 (26) | 1765 (26) |
Smoking, ever | 12,573 (61) | 40,239 (62) | 4151 (60) | 4183 (61) |
Systolic blood pressure, mmHg | 140 (126–152) | 140 (128–152) | 140 (126–150)** | 140 (126–152) |
Diastolic blood pressure, mmHg | 85 (80–90) | 85 (80–90) | 85 (80–90)** | 85 (80–90)** |
Body mass index, kg/m2 | 25.2 (22.9–27.7) | 25.6 (23.2–28.3) | 25.0 (22.8–27.5)*** | 25.0 (22.9–27.4)*** |
Alcohol, g/day | 7.6 (1.9–15.6) | 6.8 (1.3–15.3) | 7.8 (2.3–15.7)*** | 8.1 (2.3–15.9)*** |
Physically heavy work | 7659 (38) | 2613 (39) | 2444 (36)** | 2602 (38) |
Physical activity score combined | 13,300 (8460–19,785) | 6720 (4589–8460) | 13,304 (11602–15,076)*** | 23,320 (19790–29,050)*** |
Cardiovascular disease | 543 (2.6) | 205 (3.0) | 166 (2.4)* | 172 (2.5) |
Diabetes mellitus | 790 (3.8) | 305 (4.4) | 235 (3.4)** | 250 (3.6)* |
Blood pressure-lowering medication | 3568 (17) | 1323 (19) | 1177 (17)** | 1068 (16)*** |
Lipid-lowering medication | 629 (3.0) | 207 (3.0) | 205 (3.0) | 217 (3.2) |
APOE-ε4 carriersa | 3306 (30) | 1146 (31) | 1055 (30) | 1105 (30) |
Dementia diagnoses at follow-up | N events (incidence rate/1000 person-years) | |||
All-cause dementia | 1375 (4.7) | 455 (4.8) | 460 (4.7) | 460 (4.7) |
Vascular dementia | 300 (1.0) | 112 (1.2) | 101 (1.0) | 87 (0.9) |
Alzheimer’s dementia | 834 (2.9) | 266 (2.8) | 271 (2.8) | 297 (3.0) |
Age at dementia diagnosis | 80.0 (75.7–83.7) | 79.7 (75.8–83.2) | 80.2 (75.7–84.1) | 80.3 (75.8–84.1) |