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Table 2 Association between physical activity and incident dementia in the Vasaloppet cohort

From: Midlife physical activity is associated with lower incidence of vascular dementia but not Alzheimer’s disease

  All-cause dementia p Vascular dementia p Alzheimer’s dementia p
  HR (95% CI) HR (95% CI) HR (95% CI)
Physical activity
 Unadjusted model 542 events   112 events   181 events  
  Non-skiers (reference) 1   1   1  
  Skiers 0.68 (0.58–0.81) < 0.001 0.54 (0.37–0.80) 0.002 0.88 (0.66–1.18) 0.40
 Model 1 533 events   112 events   177 events  
  Non-skiers (reference) 1   1   1  
  Skiers 0.63 (0.52–0.75) < 0.001 0.49 (0.33–0.73) < 0.001 0.74 (0.55–1.00) 0.052
Excluding dementia cases < 5 years
 Unadjusted model 483 events   104 events   169 events  
  Non-skiers (reference) 1   1   1  
  Skiers 0.78 (0.65–0.93) 0.005 0.61 (0.41–0.91) 0.014 0.94 (0.69–1.27) 0.68
 Model 1 477 events   104 events   166 events  
  Non-skiers (reference) 1   1   1  
  Skiers 0.68 (0.57–0.82) < 0.001 0.54 (0.36–0.80) 0.002 0.78 (0.57–1.07) 0.12
  1. Association between physical activity and incident dementia in the Vasaloppet cohort, based on participation in a long-distance ski race (skiers) compared to non-skiers. Cox regression models showing hazard ratio (HR) with 95% confidence interval (CI) for risk of all-cause dementia, vascular dementia, or Alzheimer’s dementia, respectively. Model 1 adjusted for age, sex, and education