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Table 5 Multiple linear regression analyses with neurodegeneration biomarkers as dependent variables

From: Sleep experiences during different lifetime periods and in vivo Alzheimer pathologies

  Sleep quality Sleep duration
Betaa p Betaa p
Dependent variable: AD-CM
 Young adulthood 0.011 0.880 0.135 0.054
 Midlife − 0.058 0.418 0.173 0.015
 Current − 0.013 0.871 < 0.001 0.995
Dependent variable: AD-CT
 Young adulthood − 0.002 0.970 0.008 0.894
 Midlife − 0.017 0.779 − 0.001 0.987
 Current − 0.117 0.088 − 0.033 0.586
  1. Adjusted for age, gender, education, apolipoprotein E ε4 status, vascular risk score, use of sleep pill, Hamilton Depression Rating Score. AD-CT were natural log-transformed to achieve normal distribution
  2. AD-CM Alzheimer’s disease signature region cerebral glucose metabolism, AD-CT Alzheimer’s disease signature region cortical thickness
  3. aPositive beta value means that better sleep quality or decreased duration of sleep is associated with decreased glucose metabolism and/or cortical thickness, respectively