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Table 5 Multiple linear regression analyses with neurodegeneration biomarkers as dependent variables

From: Sleep experiences during different lifetime periods and in vivo Alzheimer pathologies

 

Sleep quality

Sleep duration

Betaa

p

Betaa

p

Dependent variable: AD-CM

 Young adulthood

0.011

0.880

0.135

0.054

 Midlife

− 0.058

0.418

0.173

0.015

 Current

− 0.013

0.871

< 0.001

0.995

Dependent variable: AD-CT

 Young adulthood

− 0.002

0.970

0.008

0.894

 Midlife

− 0.017

0.779

− 0.001

0.987

 Current

− 0.117

0.088

− 0.033

0.586

  1. Adjusted for age, gender, education, apolipoprotein E ε4 status, vascular risk score, use of sleep pill, Hamilton Depression Rating Score. AD-CT were natural log-transformed to achieve normal distribution
  2. AD-CM Alzheimer’s disease signature region cerebral glucose metabolism, AD-CT Alzheimer’s disease signature region cortical thickness
  3. aPositive beta value means that better sleep quality or decreased duration of sleep is associated with decreased glucose metabolism and/or cortical thickness, respectively