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Table 4 Multiple logistic regression analyses with AD-ND positivity as a dependent variable

From: Sleep experiences during different lifetime periods and in vivo Alzheimer pathologies

 

Sleep quality

Sleep duration

Model 1

Model 2

Model 1

Model 2

aOR (95% CI)a

p

aOR (95% CI)a

p

aOR (95% CI)

p

aOR (95% CI)

p

Young adulthood

1.428 (0.426–4.786)

0.564

1.423 (0.423–4.781)

0.569

0.826 (0.628–1.088)

0.174

0.823 (0.625–1.084)

0.166

Midlife

1.989 (0.714–5.539)

0.188

1.999 (0.708–5.641)

0.191

0.679 (0.516–0.894)

0.006

0.678 (0.514–0.893)

0.006

Current

0.693 (0.236–2.036)

0.504

0.677 (0.227–2.018)

0.484

0.938 (0.745–1.182)

0.588

0.939 (0.745–1.184)

0.594

  1. Model 1: adjusted for age, gender, education, APOE4 status, vascular risk score, use of sleep pill, Hamilton Depression Rating Score. Model 2: adjusted for covariates of model 1 + global Aβ deposition. Global Aβ deposition was natural log-transformed to achieve normal distribution
  2. AD-ND Alzheimer’s disease signature region neurodegeneration, aOR adjusted odds ratio, CI confidence interval, Aβ beta-amyloid, APOE4 apolipoprotein E ε4
  3. aGood sleep quality was taken as a reference, so aOR represents the likelihood of being AD-ND positive for bad sleep quality compared with good one
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Alzheimer's Research & Therapy

ISSN: 1758-9193