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Table 2 Association between lifetime sleep experience and Aβ positivity (or global Aβ deposition)

From: Sleep experiences during different lifetime periods and in vivo Alzheimer pathologies

 

Sleep quality

Sleep duration

Logistic regression

Linear regression

Logistic regression

Linear regression

aOR (95% CI)a

p

Betab

p

aOR (95% CI)

p

Beta

p

Young adulthood

1.864 (0.434–8.016)

0.403

0.058

0.401

1.373 (0.913–2.063)

0.128

0.099

0.148

Midlife

4.636 (1.448–14.844)

0.010

0.174

0.012

1.170 (0.804–1.703)

0.412

0.056

0.419

Current

4.194 (1.156–15.218)

0.029

0.134

0.091

0.905 (0.665–1.233)

0.528

− 0.028

0.685

  1. Both logistic and linear regression analyses were adjusted for age, gender, education, APOE4 status, vascular risk score, use of sleep pill, and Hamilton Depression Rating Score. Global Aβ deposition was natural log-transformed to achieve normal distribution
  2. beta-amyloid, aOR adjusted odds ratio, CI confidence interval, APOE4 apolipoprotein E ε4
  3. aGood sleep quality was taken as a reference, so aOR represents the likelihood of being Aβ positive for bad sleep quality compared with good one
  4. bPositive beta value means that worse sleep quality is associated with increased Aβ deposition