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Table 2 Protein targets

From: Endo-lysosomal proteins and ubiquitin CSF concentrations in Alzheimer’s and Parkinson’s disease

Protein name UniProtKB accession Gene Function
AP-2 complex subunit beta P63010 AP2B1 Subunit of the AP2 complex which is central in the formation of clathrin-coated vesicles in clathrin-mediated endocytosis [55].
Amyloid beta A4 protein P05067 APP Transmembrane protein with a number of suggested functions [56]. Processed by secretases into fragments, for example Aβ peptides [57].
Complement component C9 P02748 C9 Innate immunity component of the membrane attack complex [58].
Cathepsin B P07858 CTSB Lysosomal cysteine protease with carboxydipeptidase activity [59].
Cathepsin D P07339 CTSD Lysosomal aspartic protease [60].
Cathepsin F Q9UBX1 CTSF Lysosomal cysteine protease [59].
Cathepsin L1 P07711 CTSL Lysosomal cysteine protease [59].
Cathepsin Z Q9UBR2 CTSZ Lysosomal cysteine protease with carboxymonopeptidase activity [59].
Dipeptidyl peptidase 2 Q9UHL4 DPP7 Lysosomal protease producing dipeptides from tripeptides [61].
Ganglioside GM2 activator P17900 GM2A Extracts lipids from membranes. Required for ganglioside GM2 degradation [62].
Beta-hexosaminidase subunit beta P07686 HEXB Lysosomal β-hexosaminidase A is a heterodimeric complex composed of Beta-hexosaminidase subunit beta and subunit alpha [63]. β-hexosaminidase A hydrolyses ganglioside GM2 with the aid of ganglioside GM2 activator [62].
Lysosome-associated membrane glycoprotein 1 P11279 LAMP1 Lysosomal transmembrane protein important in vesicle fusion [64], preserving lysosomal integrity and potentially lysosomal exocytosis [65].
Lysosome-associated membrane glycoprotein 2 P13473 LAMP2 Lysosomal transmembrane protein important in vesicle fusion [64], chaperone-mediated autophagy and preserving lysosomal integrity [65].
Lysozyme C P61626 LYZ Glycan cleaving polypeptide. Produced and found in secretory vesicles of neutrophils, monocytes, macrophages and epithelial cells [66].
Tissue alpha-L-fucosidase P04066 FUCA1 Lysosomal fucosidase hydrolyzing fucose containing glycoconjugates [67].
Transcobalamin-2 P20062 TCN2 Delivers cobalamin to lysosomes where it is released [68].
Tripeptidyl-peptidase 1 O14773 TPP1 Lysosomal aspartic or serine protease producing tripeptides [69].
Ubiquitin P0CG48 Ubiquitina Labels proteins for degradation by the proteasome [12]. Has a multitude of functions as a post-translational modification [70].
  1. aUbiquitin originate from several genes and is therefore simply referred to as ubiquitin