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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Endo-lysosomal proteins and ubiquitin CSF concentrations in Alzheimer’s and Parkinson’s disease

Fig. 3

CSF endo-lysosomal proteins and ubiquitin concentrations in clinical study I. Clinical study I included cross-sectional samples from clinically characterized subjects with AD (N = 6) and PD (N = 10) as well as longitudinal samples from subjects with prodromal AD (N = 10) and stable MCI (N = 15). A significant decreased concentration of a AP2B1_868–878 (P < 0.05), b CTSF_103–116 (P < 0.05), c LAMP1_357–363 (P < 0.05), d LAMP2_133–144 (P < 0.05), e LAMP2_153–161 (P < 0.05), f LAMP2_281–289 (P < 0.01), g Ubiquitin_12–27 (P < 0.05), and h Ubiquitin_64–72 (P < 0.05) was identified in PD compared to prodromal AD. Statistics were calculated using Kruskal-Wallis test with Dunn’s test for multiple comparisons and the graphs show Tukey boxplots

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