The “rights” of precision drug development for Alzheimer’s disease

Table 2 Instruments appropriate as the outcome assessments in different phases of AD

Domain	Prevention trials	Prodromal AD trials	AD dementia trials
Cognition	PACC; APCC	NTB	ADAS-cog in mild to moderate AD; SIB in moderate to severe AD
Global/composite	None	CDR-sb; ADCOMS; iADRS	CIBIC+ in shorter trials; CDR-sb in longer trials
Function	None	ADCS ADL MCI scale; Amsterdan IADL scale	ADCS ADL scale
Behavior	NPI	NPI	NPI

ADAS-cog Alzheimer’s Disease Assessment Scale-cognitive subscale, ADCOMS Alzheimer’s Disease Composite Scale, Alzheimer’s Disease Cooperative Study Activities of Daily Living scale, APCC Alzheimer’s Prevention Initiative (API) Composite Cognitive, CDR-sb Clinical Dementia Rating-Sum of Boxes, CIBIC+ Clinical Interview-Based Impression of Change with Caregiver Input, IADL Instrumental Activities of Daily Living, iADRS Integrated Alzheimer’s Disease Rating Scale, NPI Neuropsychiatric Inventory, NTB neuropsychological test battery, PACC Preclinical Alzheimer Cognitive Composite, SIB severe impairment battery

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