From: Souvenaid in the management of mild cognitive impairment: an expert consensus opinion
Population | Prodromal ADa | Mild AD dementiab | Mild AD dementiac | Mild-moderate AD dementiad |
---|---|---|---|---|
Reference | LipiDiDiet [9] | Souvenir I [6] | S-Connect [8] | |
AD drug use | No | No | No | Yes |
Intervention duration | 24 months | 24 weeks (+ 24-week extension) | 12 weeks (+ 12-week extension) | 24 weeks |
No. of patients randomized | 311 | 259 | 225 | 527 |
Country | Finland, Germany, The Netherlands, Sweden | The Netherlands, Germany, Belgium, Spain, Italy, France | The Netherlands, Germany, Belgium, UK, USA | USA |
Ethnic origin | 99% White | Not stated | Not stated | 94% White |
Mean age (years) | 71 | 73.8 | 73.7 | 76.7 |
Male/female (%) | 49.5/50.5 | 51/49 | 50/50 | 48/52 |
Average MMSE | 26.6 | 25 | 23.9 | 19.5 |
Primary outcomes | NTB composite score measuring cognition | NTB memory domain composite score | WMS-r delayed verbal recall measuring episodic memory Modified 13-item ADAS-cog assessing cognition | 11-item ADAS-cog measuring cognition |
Secondary outcomes | CDR-SOB Brain volumes based on MRI (3D T1-weighted anatomical scans of total hippocampal, whole brain, and ventricular volumes Progression to dementia Nutritional blood parameters | NTB executive function domain NTB total composite score DAD EEG Nutritional blood parameters | ADCS-ADL WMS-r immediate verbal recall CIBIC-plus NPI QOL-AD Nutritional blood parameters | Cognitive test battery (Digit Span-WMS, concept shifting test, letter digit substitution test, and category fluency) ADCS-ADL CDR-SOB Nutritional blood parameters |