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Table 3 Risk of mild cognitive impairment and dementia across the different combinations of presentation (n = 13,462)

From: Depression, subjective cognitive decline, and the risk of neurocognitive disorders

Different combinations of presentation HR (95% CI)a P value Median time to MCI and dementia, year (95% CI)b
No depression or SCD 1.0 (Ref) Ref 12.2 (12.1–12.3)
Depression only 1.4 (1.1–1.7) 0.004 12.1 (11.6–12.2)
SCD only 2.0 (1.8–2.2) < 0.001 9.8 (9.1–10.2)
Both depression and SCD 2.8 (2.4–3.4) < 0.001 7.2 (5.2–9.1)
  1. HR hazard ratio, CI confidence interval, MCI mild cognitive impairment, SCD subjective cognitive decline, Ref reference group
  2. aModel adjusted for baseline variables of age, sex, ethnicity, years of education, family history of dementia, current smoking, diabetes mellitus, hypertension, hyperlipidemia, and Mini-Mental State Examination score
  3. bThe 95% CI was computed with 1000 bootstrap sampling