Fig. 2

Serial FDG-PET imaging of relative cerebral metabolism (SUVR): Cerebral metabolism to FDG-PET improved at follow-up imaging 3 months after initiating late-stage Anle138b treatment in hTau mice when compared to own baseline, with an already established baseline reduction in comparison to non-carrier control mice (a, compare both upper rows). On the other hand, we saw ongoing metabolic decline in the vehicle-treated hTau group (a, compare both lower rows). Quantification of longitudinal changes in relative FDG uptake (ΔSUVR) to PET indicates normalization of cerebral metabolism with prolonged Anle138b administration, but ongoing decrease in the frontal cortex (b) and the hippocampus (c) in the hTau vehicle group. Non-carrier controls do not show any relevant changes of relative FDG uptake over time. Data are adjusted for baseline imaging. BL baseline at 14.5 months of age, FU follow-up at 17.5 months. Error bars represent SEM