Variable | Beta | 95% CI | p value |
---|---|---|---|
CDR Sum of Boxes | |||
Log-transformed WMH | 0.12 | [0.06, 0.19] | < 0.01 |
Hippocampal volume | − 0.19 | [− 0.29, − 0.07] | < 0.01 |
Total brain volume | − 0.15 | [− 0.23, − 0.06] | < 0.01 |
Semantic Fluency | |||
Log-transformed WMH | − 0.03 | [− 0.04, − 0.02] | < 0.01 |
Hippocampal volume | 0.02 | [0.01, 0.04] | < 0.01 |
Total brain volume | 0.02 | [0.01, 0.04] | < 0.01 |
TMT-A | |||
Log-transformed WMH | 0.03 | [0.02, 0.04] | < 0.01 |
Hippocampal volume | − 0.03 | [− 0.04, − 0.01] | < 0.01 |
Total brain volume | − 0.02 | [− 0.04, − 0.01] | < 0.01 |
TMT-B | |||
Log-transformed WMH | 0.04 | [0.02, 0.05] | < 0.01 |
Hippocampal volume | − 0.03 | [− 0.05, − 0.01] | < 0.01 |
Total brain volume | − 0.03 | [− 0.05, − 0.01] | < 0.01 |
LM-IA | |||
Log-transformed WMH | − 0.04 | [− 0.07, − 0.01] | 0.01 |
Hippocampal volume | 0.03 | [0.01, 0.06] | 0.01 |
Total brain volume | 0.02 | [− 0.02, 0.04] | 0.23 |
LM-IIA | |||
Log-transformed WMH | − 0.03 | [0.06, − 0.00] | 0.02 |
Hippocampal volume | 0.04 | [0.01, 0.06] | 0.01 |
Total brain volume | 0.01 | [− 0.02, 0.03] | 0.50 |
WAIS-R DSC | |||
Log-transformed WMH | − 0.04 | [− 0.06, − 0.02] | < 0.01 |
Hippocampal volume | 0.02 | [0.00, 0.03] | 0.03 |
Total brain volume | 0.02 | [0.01, 0.04] | 0.01 |
GDS-15 | |||
Log-transformed WMH | 0.02 | [0.01, 0.04] | < 0.01 |
Hippocampal volume | − 0.01 | [− 0.03, 0.00] | 0.08 |
Total brain volume | − 0.01 | [− 0.03, 0.02] | 0.61 |