Table 1 Characteristics of the study cohort. Small vessel disease and cerebral amyloid angiopathy scoring were performed on a 4-point scale [26, 30]. Although the cohorts were matched for age, gender and post-mortem interval, there was weak evidence of a between-group difference in age at death. Analyses were therefore carried out both with and without age as a covariate
AD with visual hallucinations, n = 23 | AD without visual hallucinations, n = 19 | Dementia with Lewy bodies, n = 19 | Controls, n = 36 | Statistical findings | p with age as covariate | |||||
|---|---|---|---|---|---|---|---|---|---|---|
Mean | SD | Mean | SD | Mean | SD | Mean | SD | |||
Age (years) | 76.7 | 9.0 | 79.3 | 9.0 | 81.0 | 7.0 | 82.1 | 6.3 | ANOVA p = 0.065 | |
Post-mortem interval (h) | 36.7 | 21.1 | 41.8 | 16.3 | 33.3 | 18.1 | 36.9 | 15.6 | ANOVA p = 0.533 | |
Age at onset of dementia (years) | 66.9 | 10.4 | 66.4 | 10.1 | 73.0 | 6.9 | N/A | N/A | Kruskal-Wallis p = 0.164, χ2 = 3.611 | |
Duration of dementia (years) | 9.7 | 4.2 | 11.1 | 3.4 | 7.6 | 4.6 | N/A | N/A | ANOVA p = 0.04 | 0.0340 |
Mean Braak stage | 5.5 | 0.5 | 5.3 | 0.9 | 3.1 | 1.5 | 2.0 | 0.8 | χ2 = 109.9, p < 0.001 | |
Cerebral amyloid angiopathy score | ||||||||||
0 | 3 | 3 | 9 | 24 | χ2 = 31.37, p < 0.001 | |||||
1 | 7 | 3 | 3 | 3 | ||||||
2 | 7 | 8 | 2 | 3 | ||||||
3 | 6 | 4 | 5 | 3 | ||||||
Occipital small vessel disease score | ||||||||||
0 | 2 | 2 | 3 | 8 | χ2 = 8.07, p = 0.527 | |||||
1 | 11 | 6 | 5 | 10 | ||||||
2 | 6 | 3 | 1 | 6 | ||||||
3 | 0 | 2 | 1 | 1 | ||||||