Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study

Table 3 Associations between endorsement of SCD-plus features and SCD-I domains with CSF-Aß-42 level

N = 205	CSF-Aß-42 level (pg/ml)						p ^a
N = 205			M	(SD)	F	\( {\eta}_p^2 \)	p ^a
SCD-plus features
Decline in memory	Yes	n = 129	720	− 316	7.65**	.036	.006
Decline in memory	No	n = 76	849	− 293
Onset of SCD within the last 5 years	Yes	n = 120	722	− 312	6.07*	.029	.015
Onset of SCD within the last 5 years	No	n = 85	833	− 306
Particular concerns/worries	Yes	n = 113	727	− 309	3.68	.018	.056
Particular concerns/worries	No	n = 92	819	− 313
The feeling of worse performance than others	Yes	n = 35	695	− 308	2.488	.012	.116
The feeling of worse performance than others	No	n = 170	783	− 313
Confirmation by an informant	Yes	n = 81	695	− 315	4.19*	.032	.017
Confirmation by an informant	No	n = 124	816	− 304
SCD-I domains
Decline in memory	Yes	n = 129	720	− 316	7.65**	.036	.006
Decline in memory	No	n = 76	849	− 293
Decline in language	Yes	n = 127	727	− 312	5.18*	.025	.024
Decline in language	No	n = 78	835	− 306
Decline in attention	Yes	n = 62	738	− 349	.751	.004	.387
Decline in attention	No	n = 143	781	− 297
Decline in planning	Yes	n = 26	704	− 326	1.049	.005	.307
Decline in planning	No	n = 179	777	− 312
Decline in other	Yes	n = 48	716	− 302	1.65	.008	.201
Decline in other	No	n = 156	780	− 313

M mean, SD standard deviation
*p < .05
**p < .01
***p < .001
^aAdjusted for age for the SCD-I domains and for age and education for the SCD-plus features, \( {\eta}_p^2 \) > .01 = small effect; \( {\eta}_p^2 \) > .06 = average effect; \( {\eta}_p^2 \) > .14 = large effect (according to Cohen 1988)

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